Planta Med 2010; 76 - P156
DOI: 10.1055/s-0030-1264454

Shikonin derivatives from the roots of Onosma nigricaule (Boraginaceae)

U Özgen 1, G Bulut 1, C Kazaz 2, H Seçen 2
  • 1Atatürk University, Faculty of Pharmacy, Department of Pharmacognosy, 25240 Erzurum, Turkey
  • 2Atatürk University, Faculty of Sciences, Deparment of Chemistry, 25240 Erzurum, Turkey

The genus Onosma (Boraginaceae) is represented by 87 species in Turkey [1]. The roots of some Onosma species are used for wound healing and burns [2,3] in Turkey. Onosma nigricaule is an endemic species for Turkey [1] and its roots are used for wound healing and burns in Erzurum Province. In this sudy, the roots of O. nigricaule (500g) were extracted with n-hexane:dichloromethane (1:1) (2L x 3) and then filtered. The filtrate was evaporated at 40°C. Three shikonin derivatives (deoxyshikonin (1), β,β-dimethylacryl shikonin (2), and acetyl shikonin (3)) were isolated from this extract by using several chromatographic methods. The structures of the pure compounds were elucidated by using 1H-NMR and 13C-NMR Spectroscopy, and ESI-MS.

Acknowledgements: The authors would like to thank Prof. Dr. Mehmet Koyuncu (Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Ankara) for identification of the plant material.

References: 1. Riedl H. (1978) Onosma L. Flora of Turkey and the East Aegean Islands. Vol. 6, pp. 326–376. Edinburgh University Press, UK.

2. Ozgen U., Ikbal M., Hacimuftuoglu A., Houghton P.J., Gocer F., Dogan H., Coskun M. (2006)J. Ethnopharmacol. 104:100–103.

3. Cadirci E., Suleyman H., Aksoy H., Halici Z., Ozgen U., Koc A., Ozturk N. (2007) Chem. Biol. Interact. 170(1):40–48.