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Pre-myrsinanes and deoxygenated phorboids from the Iranian spurge Euphorbia macroclada Boiss.
VEGFR antagonism was recently reported for some myrsinane polyesters , a very surprising observation since kinase inhibitors are generally flat molecules that act as an ATP-mimics, while myrsinanes diterpenoids are exuberant in terms of tridimensional chirality and structural complexity. This report prompted us to systematically investigate a series of spurges for the presence of myrsinane-type polyesters, and we report that Euphorbia macroclada Boiss, a spurge endemic to the Iranian plateau, is a good source of this type of compounds. It had previously been reported to contain cytotoxic  principles; besides the new pre-myrsinane polyesters 1a, 1b and 2, a series of deoxygenated phorboids of general formula 3 (R1=H, Ac, 4H=-β or -α; R2=short alkyl chain) were obtained.
All new compounds were structurally elucidated by spectroscopic methods, and especially 2D NMR measuremets.
References: 1. Hussain, S. et al. (2008). BMC Cell Biology.9:7.
2. Sadeghi-Aliabadi, H. et al. (2009) IJPR. 5:103–108.