Planta Med 2010; 76 - P144
DOI: 10.1055/s-0030-1264442

Evaluation of the burn healing properties of five Iranian medicinal plants in diabetic rats

A Ghasemi Pirbalouti 1, S Azizi 2, A Koohpayeh 1, A Golparvar 3
  • 1Research Centre of Medicinal Plants & Ethnoveterinary, Islamic Azad University, Shahrekord Branch, Medicinal Plants, Iran-Shahrekord-Rahmatyeh-POBox:166, 88148 Shahrekord, Iran, Islamic Republic Of
  • 2Veterinary Medicine Faculty, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran, Department of Pathology, Islamic Azad University, Shahrekord Branch, POBox: 166, Shahrekord, Iran, 88148 Shahrekord, Iran, Islamic Republic Of
  • 3Agriculture Faculty, Islamic Azad University, Khorasgan Branch, Isfahan, Iran, Department of Plant Breeding, Islamic Azad University, Khorasgan Branch, Isfahan, Iran, 81595–158 Isfahan, Iran, Islamic Republic Of

Some of the medicinal plants in Iranian traditional medicine (Unani) whose have been used as remedy against edema, burn, wound and for their carminative, antimicrobial and anti-inflammatory activities [1, 2]. For example, Malva sylvestris L. (Malvaceae), Punica granatum L. (Punicaceae), Prunus amygdalus L. (Rosaceae), Arnebia euchroma Rolye (Johnst) (Boraginaceae) and Scrophularia deserti Del. (Scrophulariaceae) used for wound and burn healing by tribal communities in Iran[3]. The ethanol extracts of Malva sylvestris and P. granatum flowers, P. amygdalus leaves, A. euchroma roots and S. deserti were used to evaluate the burn healing activity at 200mg/kg/day dose in alloxan-induced diabetic rats. Burns were induced in Wistar rats divided into nine groups as following; Group-1, normal rats were treated with simple ointment base. Group-2, diabetic rats were treated with simple ointment base (control). Groups-3 and -7, diabetic rats were treated with simple ointment base containing of extracts (diabetic animals), Groups 8, diabetic rats were treated with simple ointment base containing of mixed extracts, Group-9, diabetic rats received the standard drug (Silver sulphadiazine). The efficacy of treatment was evaluated based on burn wound area relative and histopathological characteristics. The extract-treated diabetic animals showed significant reduction in the wound area when compared with control. Also, histopathological studies of the tissue obtained on days 9th and 16th from the extract-treated by extracts showed increased well organized bands of collagen, more fibroblasts and few inflammatory cells.

References: 1. Ghasemi Pirbalouti A, et al. (2009) Pharmacognosy Mag. 5: 433–437.

2. Zargari A. (1989–1992) Medicinal Plants. University Publication of Tehran, Iran.

3. Ghasemi Pirbalouti A. (2009) Herba Polonica. 55: 69–75.