Skull Base 2011; 21(1): 037-046
DOI: 10.1055/s-0030-1263285

© Thieme Medical Publishers

Evaluation of the Prognostic Indicators of Giant Intracranial Aneurysms

Prasad S.S.V Vannemreddy1 , 2 , Ali Nourbakhsh2 , Anil Nanda2
  • 1Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad, India
  • 2Louisiana State Health Sciences Center, Shreveport, Louisiana
Further Information

Publication History

Publication Date:
16 August 2010 (online)


The indicators of poor outcome in giant intracranial aneurysms have been the subject of several studies in the literature. We conducted a retrospective analysis to evaluate the predictors of poor outcome in giant intracranial aneurysms. We studied consecutive cases with aneurysms admitted over a 9-year period in our institution. All the aneurysms were treated with clipping. Patient demographics, clinical profile, and aneurysm characteristics were evaluated in a multivariate analysis as probable indicators of Glasgow Outcome Scale (GOS) score. The outcome of the aneurysms (GOS score) was compared with the remaining non-giant aneurysms. A total of 41 giant and 348 non-giant aneurysms were identified in our series. In the multivariate analysis, the indicators of poor outcome were identified as poor clinical grade (p < 0.0004), intraoperative rupture (p < 0.007), and posterior circulation of the aneurysms (p < 0.01). Non-giant aneurysms had a better outcome compared with the giant aneurysms (p < 0.01). Giant aneurysms impose a relatively higher risk of morbidity and mortality to the patients. The predictors of the postsurgical outcome of the giant aneurysms include the clinical condition of the patient, location of the aneurysm, and intraoperative rupture.


Prasad S.S.V Vannemreddy, M.D. , M.S. , M.Ch. 

LSUHSC-Neurosurgery, 1501 Kings' Highway, Shreveport

LA 71103