Asymmetric Palladium-Catalyzed Allylic Alkylation of Indoles

Significance

The authors exploit the intrinsic chirality of a sulfur donor atom in their sulfur-MOP ligand to increase the stereocontrol of the catalyst system in their alkylation of indoles. Optically ­active indoles are common in biologically active compounds, and good yields and enantioselectivities can be achieved for these types of molecules with this methodology.