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Synfacts 2011(6): 0625-0625
DOI: 10.1055/s-0030-1260396
DOI: 10.1055/s-0030-1260396
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Construction of Quaternary Stereogenic Centers from Tertiary Boronic Esters
R. P. Sonawane, V. Jheengut, C. Rabalakos, R. Larouche-Gauthier, H. K. Scott, V. K. Aggarwal*
University of Bristol, UK
Further Information
Publication History
Publication Date:
19 May 2011 (online)
Significance
The authors report on a lithiation-borylation reaction with subsequent one-carbon homologation or vinylation. The ready availability of the starting materials, broad range of substrates, bearing versatile functional groups with quaternary stereogenic centers, and very high enantioselectivities are noteworthy.