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Synfacts 2011(6): 0653-0653  
DOI: 10.1055/s-0030-1260362
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Ni-Catalyzed Alkyne Cycloaddition to Give Boronic Esters

Contributor(s): Paul Knochel, Andreas K. Steib
A.-L. Auvinet, J. P. A. Harrity*
University of Sheffield, UK
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Publication History

Publication Date:
19 May 2011 (online)

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Significance

A new nickel-catalyzed benzannulation of cyclobutenones with alkynylboronates to yield aromatic boronic esters has been disclosed. Furthermore, a one-pot cycloaddition-coupling protocol has been developed, whereby the nickel catalyst performs firstly the benzannulation and afterwards the cross-coupling.