Mechanistic Studies on a New
Catalyst System (CuI-NaHSO4×SiO2)
Leading to the One-Pot Synthesis of Imidazo[1,2-a]pyridines from Reactions of 2-Aminopyridines,
Aldehydes, and Terminal Alkynes

Sarita Mishra; Rina Ghosh

doi:10.1055/s-0030-1260255

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Synthesis 2011(21): 3463-3470
DOI: 10.1055/s-0030-1260255

PAPER

Mechanistic Studies on a New Catalyst System (CuI-NaHSO₄×SiO₂) Leading to the One-Pot Synthesis of Imidazo[1,2-a]pyridines from Reactions of 2-Aminopyridines, Aldehydes, and Terminal Alkynes

Sarita Mishra, Rina Ghosh*
Department of Chemistry, Jadavpur University, Kolkata 700032, India
Fax: +91(33)24146266.; e-Mail: ghoshrina@yahoo.com; e-Mail: ghosh_rina@hotmail.com;

Further Information

Publication History

Received 12 July 2011
Publication Date:
06 October 2011 (online)

Abstract
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Abstract

One-pot reactions of aldehydes, 2-aminopyridines, and terminal alkynes, in the presence of the copper(I) iodide-NaHSO₄˙SiO₂ combination catalyst in refluxing toluene, generate the corresponding imidazo[1,2-a]pyridines in high to excellent yields; the mechanism has been studied.

Key words

CuI-NaHSO₄˙SiO₂ - one-pot synthesis - imidazo[1,2-a]pyridine - 2-aminopyridine - cascade reaction

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