One-pot reactions of aldehydes, 2-aminopyridines, and terminal
alkynes, in the presence of the copper(I) iodide-NaHSO4˙SiO2 combination
catalyst in refluxing toluene, generate the corresponding imidazo[1,2-a]pyridines in high to excellent yields;
the mechanism has been studied.
CuI-NaHSO4˙SiO2
- one-pot
synthesis - imidazo[1,2-a]pyridine - 2-aminopyridine - cascade reaction