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Synthesis 2011(21): 3463-3470  
DOI: 10.1055/s-0030-1260255
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© Georg Thieme Verlag Stuttgart ˙ New York

Mechanistic Studies on a New Catalyst System (CuI-NaHSO4×SiO2) Leading to the One-Pot Synthesis of Imidazo[1,2-a]pyridines from Reactions of 2-Aminopyridines, Aldehydes, and Terminal Alkynes

Sarita Mishra, Rina Ghosh*
Department of Chemistry, Jadavpur University, Kolkata 700032, India
Fax: +91(33)24146266.; e-Mail: ghoshrina@yahoo.com; e-Mail: ghosh_rina@hotmail.com;
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Publication History

Received 12 July 2011
Publication Date:
06 October 2011 (online)

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Mechanistic Studies on a New Catalyst System (CuI-NaHSO4×SiO2) Leading to the One-Pot Synthesis of Imidazo[1,2-a]pyridines from Reactions of 2-Aminopyridines, Aldehydes, and Terminal AlkynesSynthesis 2011; 2011(21): e3-e3
DOI: 10.1055/s-0031-1289297

Abstract

One-pot reactions of aldehydes, 2-aminopyridines, and terminal alkynes, in the presence of the copper(I) iodide-NaHSO4˙SiO2 combination catalyst in refluxing toluene, generate the corresponding imidazo[1,2-a]pyridines in high to excellent yields; the mechanism has been studied.

Key words

CuI-NaHSO4˙SiO2 - one-pot synthesis - imidazo[1,2-a]pyridine - 2-aminopyridine - cascade reaction