Synthesis of β-Aminocyclohexanones and β-Aminocyclohexanols through an Intramolecular Tandem Isomerization-Mannich Reaction as a Key Step

Abstract

New β-aminocyclohexanones and β-aminocyclohexanols, with a primary amino group, have been obtained by a short and efficient sequence involving an intramolecular tandem isomerization-Mannich reaction as the key step. This methodology takes advantage of tert-butanesulfinyl protection of the nitrogen atom.

isomerization - catalysis - nickel - carbocycles - Mannich

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