Ligand-free palladium-catalyzed Suzuki-Miyaura cross-coupling
of iodoethynes with arylboronic acids under aerobic conditions has
been developed. In the presence of palladium(II) acetate and cesium
carbonate, a variety of iodoethynes underwent the Suzuki-Miyaura
cross-coupling reaction with arylboronic acids at room temperature
to afford the corresponding internal alkynes in moderate to good
yields. It is noteworthy that this protocol proceeds under mild
and aerobic conditions without the aid of ligands.
palladium - iodoethynes - arylboronic acids - Suzuki-Miyaura - cross-coupling - alkynes
