Reaction of Ethyl 5-Acetyl-3,4-dihydropyridine-1(2H)-carboxylate with 1,3-N,N-Bis-nucleophiles:
A Facile Access to Novel Pyrimidine Derivatives

Nazar B. Maximov; Pavel K. Mykhailiuk; Andrei I. Kisel; Zoia V. Voitenko; Andrey A. Tolmachev

doi:10.1055/s-0030-1259970

PAPER

Reaction of Ethyl 5-Acetyl-3,4-dihydropyridine-1(2H)-carboxylate with 1,3-N,N-Bis-nucleophiles: A Facile Access to Novel Pyrimidine Derivatives

Nazar B. Maximov^a,b, Pavel K. Mykhailiuk*^a,b, Andrei I. Kisel^b, Zoia V. Voitenko^b, Andrey A. Tolmachev^a,b
^a Enamine Ltd., Alexandra Matrosova Street 23, 01103 Kiev, Ukraine
^b Department of Chemistry, Kiev National Taras Shevchenko University, Volodymyrska Street 64, 01033 Kiev, Ukraine
Fax: +380(44)2351273; e-Mail: pavel.mykhailiuk@gmail.com;

Abstract

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Abstract

Reaction of ethyl 5-acetyl-3,4-dihydropyridine-1(2H)-carboxylate with diverse 1,3-N,N-bis-nucleophiles results in the regioselective formation of the correspondingly substituted pyrimidines in good yields.

Key words

pyrimidines - amidines - amino heterocycles - tetrahydropyridine

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References

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