Synlett 2010(19): 2857-2860  
DOI: 10.1055/s-0030-1259033
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Novel and Efficient Synthesis of Unsymmetrical Trisulfides

Slawomir Lach, Magdalena Sliwka-Kaszynska, Dariusz Witt*
Department of Organic Chemistry, Chemical Faculty, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, Poland
Fax: +48(58)3472694; e-Mail: [email protected];
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Publikationsverlauf

Received 9 August 2010
Publikationsdatum:
10. November 2010 (online)

Abstract

We have developed a convenient method for the synthesis of unsymmetrical trisulfides under mild conditions in very good yields. The designed method is based on the straightforward preparation of 1-[(5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)trisulfanyl]dodecane from readily available 5,5-dimethyl-2-sulfanyl-2-thioxo-1,3,2-dioxaphosphorinane, sulfur dichloride (SCl2) and dodecane-1-thiol. The unsymmetrical trisulfides can be obtained from aliphatic, aromatic thiols and l-cysteine derivatives as well.

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