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Synfacts 2010(10): 1164-1164
DOI: 10.1055/s-0030-1258682
DOI: 10.1055/s-0030-1258682
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Lewis Acid/Lewis Base Assisted Asymmetric Grignard Reaction
X.-Y. Fan, Y.-X. Yang, F.-F. Zhuo, S.-L. Yu, X. Li, Q.-P. Guo, Z.-X. Du, C.-S. Da*
Lanzhou University, P. R. of China
Further Information
Publication History
Publication Date:
22 September 2010 (online)
Significance
Judicious choice of additives allows for the addition of aryl Grignards to aldehydes with excellent yields and enantioselectivities. Importantly, the reaction takes place at room temperature in only three hours. Both aromatic and aliphatic aldehydes are well tolerated.