Synfacts 2010(10): 1150-1150  
DOI: 10.1055/s-0030-1258681
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium(II)-Catalyzed Dicarboxylation of Chiral Allylic Alcohols

Contributor(s): Hisashi Yamamoto, Patrick Brady
O. Hamed, P. M. Henry, D. P. Becker*
Loyola University Chicago, USA
Further Information

Publication History

Publication Date:
22 September 2010 (online)

Significance

The authors describe a method for the dicarboxylation of allylic alcohols to generate products bearing three contiguous stereogenic centers. The reaction proceeds at room temperature with up to 98% conservation of enantiomeric excess.