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Synfacts 2010(10): 1187-1187
DOI: 10.1055/s-0030-1258672
DOI: 10.1055/s-0030-1258672
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Allylboration of Aldehydes
P. Jain, J. C. Antilla*
University of South Florida, Tampa, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. September 2010 (online)
Significance
A highly enantioselective allylboration of aldehydes catalyzed by the chiral Brønsted acid (R)-TRIP is reported by the authors. This transformation shows a broad substrate scope: aryl, heteroayrl, α,β-unsaturated and aliphatic aldehydes can all be efficiently allylated. Furthermore, the crotylboration of benzaldehyde also proceeded smoothly with high diastereo- and enantioselectivity in the presence of this acid catalyst.