Cobalt(I) Catalysis in the Diastereoselective Two-Step Synthesis of Tricyclic Systems

Abstract

The diastereoselective two-step synthesis of heterotricyclic systems is accomplished by regioselective cobalt-catalysed [4+2]- and [4+2+2]-cycloaddition reactions generating cyclohexa-1,4-diene and cycloocta-1,3,6-triene derivatives, and a hetero-Diels­-Alder reaction. Thus, a set of selected cyclohexadienes and cyclooctatrienes were reacted with cyclic 1,3-diones and formaldehyde in a Knoevenagel-hetero-Diels-Alder multicomponent reaction to produce a variety of tricyclic products.

alkyne - catalysis - cobalt - cycloaddition - diene - multicomponent reaction - hetero-Diels-Alder reaction

References

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The X-ray data have been deposited at the Cambridge Crystallographic Data Centre and allocated the deposition numbers CCDC 809255 (6a) and CCDC 809256 (6d). These data can be obtained free of charge at www.ccdc.cam.ac.uk/conts/retrieving.html [or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: [phone], E-mail: [e-mail]].