Expeditious Synthesis of Trifluoromethylated
Heterocycles: Noncatalytic 1,3-Dipolar Cyclization of Azomethine
Imines with (α-Trifluoromethyl)acrylates

Shinichi Ogawa; Takayuki Nishimine; Etsuko Tokunaga; Norio Shibata

doi:10.1055/s-0030-1258189

PAPER

Expeditious Synthesis of Trifluoromethylated Heterocycles: Noncatalytic 1,3-Dipolar Cyclization of Azomethine Imines with (α-Trifluoromethyl)acrylates

Shinichi Ogawa, Takayuki Nishimine, Etsuko Tokunaga, Norio Shibata*
Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan
Fax: +81(52)7357543; e-Mail: nozshiba@nitech.ac.jp;

Abstract

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Abstract

A convenient, simple, and expeditious procedure for the preparation of novel trifluoromethylated bicyclic pyrazolidinone systems by noncatalytic 1,3-dipolar cyclization of azomethine imines with tert-butyl 2-(trifluoromethyl)prop-2-enoate is presented.

Key words

bicyclic compounds - fluorine - cycloadditions - heterocycles - imines - drugs

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References

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