Kardiologie up2date 2011; 7(4): 269-275
DOI: 10.1055/s-0030-1257054
Hotline – Koronare Herzerkrankung und Atherosklerose

© Georg Thieme Verlag KG Stuttgart · New York

Bedeutung von Chemokinen in der Atherogenese

Andreas  Schober
Further Information

Publication History

Publication Date:
02 February 2012 (online)

Abstract

The accumulation of monocyte-derived macrophages in the arterial wall is crucial for the development of atherosclerotic plaques. Chemokines direct many aspects of the atherogenic monocyte recruitment, such as the peripheral monocyte count, the adhesion and transendothelial migration of monocytes, and the survival of plaque macrophages. Therefore, chemokines and its receptors are promising targets in the treatment of atherosclerosis. However, despite the availability of numerous compounds which target chemokines or chemokine receptors, clinical trials which study the effect of these pharmaceuticals on atherosclerosis in patients are currently missing.

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Univ.-Prof. Dr. med. Andreas Schober

Institut für Molekulare Herz-Kreislaufforschung
Medizinische Fakultät der RWTH Aachen

Pauwelsstr. 30
52074 Aachen

Email: [email protected]