Endoscopy 2011; 43(12): 1097-1099
DOI: 10.1055/s-0030-1256895
Case report/series
© Georg Thieme Verlag KG Stuttgart · New York

Endoscopic injection of autologous blood for bleeding gastroduodenal ulcers

A. Schneider
Department of Gastroenterology, Hepatology, and Gastroenterological Oncology, Bogenhausen Academic Teaching Hospital, Klinikum Muenchen GmbH, Germany
,
W. Schepp
Department of Gastroenterology, Hepatology, and Gastroenterological Oncology, Bogenhausen Academic Teaching Hospital, Klinikum Muenchen GmbH, Germany
› Author Affiliations
Further Information

Publication History

21 February 2011

20 May 2011

Publication Date:
06 October 2011 (online)

Endoscopic injection of diluted epinephrine and the application of endoclips or thermal probes are established endoscopic therapies for peptic ulcer bleeding (PUB). However, autologous blood may offer advantages at least over diluted epinephrine due to its specific properties: corpuscular components may provide prolonged persistence and procoagulatory constituents may additionally prevent recurrent bleeding. We performed successful endoscopic injection of autologous blood for acute spurting (Forrest Ia) or oozing (Ib) bleeding from duodenal or gastric ulcers. The injection of autologous blood was simple to apply and achieved hemostasis in bleeding Forrest I peptic ulcers. This technique can be considered as an adjunct or an alternative to other methods for endoscopic control of PUB.

 
  • References

  • 1 Cook DJ, Guyatt GH, Salena BJ, Laine LA. Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: a meta-analysis. Gastroenterology 1992; 102: 139-148
  • 2 Leontiadis GI, Sharma VK, Howden CW. Proton pump inhibitor therapy for peptic ulcer bleeding: Cochrane collaboration meta-analysis of randomized controlled trials. Mayo Clin Proc 2007; 82: 286-296
  • 3 Shastri YM, Kriener S, Caspary WF, Schneider A. Autologous blood as a submucosal fluid cushion for endoscopic mucosal therapies: results of an ex vivo study. Scand J Gastroenterol 2007; 42: 1369-1375
  • 4 Park CH, Joo YE, Kim HS et al A prospective, randomized trial comparing mechanical methods of hemostasis plus epinephrine injection to epinephrine injection alone for bleeding peptic ulcer. Gastrointest Endosc 2004; 60: 173-179
  • 5 Vergara M, Calvet X, Gisbert JP. Epinephrine injection versus epinephrine injection and a second endoscopic method in high risk bleeding ulcers. Cochrane Database Syst Rev 2007; CD005584