Diagnostik primär kutaner B-Zell-Lymphome

Zusammenfassung

Primär kutane B-Zell-Lymphome (PCBCL) sind seltene Erkankungen der Haut. Die drei wichtigsten Subtypen sind die indolent verlaufenden primär kutanen follikulären Lymphome (PCFCL) und die primär kutanen Marginalzonenlymphome (PCMZL) sowie das deutlich aggressiver verlaufende primär kutane diffus großzellige B-Zell-Lymphom des Beines (PCLBCL, LT). Bei der Verdachtsdiagnose PCBCL muss zunächst ein nodales Lymphom mit sekundärer Hautbeteiligung durch entsprechende Staginguntersuchungen ausgeschlossen werden. Die Differenzierung zwischen den einzelnen Subtypen ist in den meisten Fällen mittels Anamnese, Klinik und (Immun)-Histologie möglich. In Einzelfällen erscheinen molekular-biologische Untersuchungen gerechtfertigt.

Abstract

Primary cutaneous B-cell lymphomas (PCBL) are rare skin tumors. The three major subtypes are the indolent variants primary cutaneous follicle centre lymphoma (PCFCL) and primary cutaneous marginal zone lymphoma (PCMZL), and the more aggressive PCBCL primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL, LT). After a nodal lymphoma with secondary skin involvement has been excluded by staging procedures, the differentiation between the subtypes is in most cases possible by the medical history, clinical examination and (immuno)-histochemical analysis. However, in some cases molecular analyses are required to achieve diagnosis.

█Schlüsselwörter

Primär kutane B-Zell-Lymphome - PCFCL - PCMZL - PCLBCL - LT

█Key words

primary cutaneous B-cell lymphoma - PCFCL - PCMZL - PCLBCL - LT

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