Toll-like Receptor 4 and Hepatic Fibrogenesis

Jean-Philippe Pradere; Juliane S Troeger; Dianne H Dapito; Ali A Mencin; Robert F Schwabe

doi:10.1055/s-0030-1255353

Seminars in Liver Disease, Table of Contents

Semin Liver Dis 2010; 30(3): 232-244
DOI: 10.1055/s-0030-1255353

Toll-like Receptor 4 and Hepatic Fibrogenesis

Jean-Philippe Pradere¹ , Juliane S. Troeger¹ , Dianne H. Dapito² , Ali A. Mencin¹ , Robert F. Schwabe¹ ^, ²

¹Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York
²The Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, New York, New York

Abstract

ABSTRACT

Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver. Here, we review mechanisms by which TLR4 and TLR4 ligands from the intestinal microbiota contribute to hepatic injury, inflammation, hepatic stellate cell activation, and fibrosis.

KEYWORDS

LPS - TLR4 - hepatic injury - fibrogenesis

Full Text

References

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