Int J Sports Med 2010; 31(8): 537-541
DOI: 10.1055/s-0030-1254115
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

Anti-Sports Anaemia Effects of Verbascoside and Martynoside in Mice

M. Zhu1 , 2 , N. Tan1 , H. Zhu3 , G. Zeng1 , W. He1 , B. Yu2 , X. Chen2
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
  • 2Institute of Sports Science, Zhanjiang Normal College, Zhanjiang, China
  • 3Institute of Sports Science, Huanan Normal University, Guangzhou, China
Further Information

Publication History

accepted after revision April 12, 2010

Publication Date:
16 June 2010 (online)

Abstract

This paper aims to investigate the effects of verbascoside and martynoside isolated from Pedicularis dolichocymba on sports anaemia. Forty mice were divided into four groups: Group R (control group, nonsupplemented and maintained at rest), Group E (nonsupplemented and undergoing exercise), Group VE (supplemented with verbascoside 10 mg/kg per day and undergoing exercise), and Group ME (supplemented with martynoside 10 mg/kg per day and undergoing exercise). After 5 weeks intensive swimming exercises, we measured the RBC count, the hemoglobin concentration, the hematocrit (Hct), the mean corpuscular hemoglobin concentration (MCHC) and the mean corpuscular hemoglobin (MCH). We studied the shapes of RBC and measured the plasma malonyldialdehyde (MDA). We found Group E showed lower RBC, hemoglobin and Hct levels, higher MCHC, MCH, plasma MDA levels and the abnormally shaped RBCs percentage than Groups R, VE and ME. Group ME showed lower RBC and Hct levels, higher MCH, plasma MDA levels and the abnormally shaped RBCs percentage than Group VE. The results indicated that verbascoside and martynoside have the potential of antagonizing sports anaemia, the mechanism of this effect might be related to preventing RBC from free radical damage. Moreover, verbascoside was found to be more active than martynoside.

References

Correspondence

Prof. Dr. Ninghua Tan

State Key Laboratory of

Phytochemistry and Plant

Resources in West China

Kunming Institute of Botany

Chinese Academy of Sciences

132# Lanhei Road, Heilongtan

Kunming 650204

China

Phone: +86/871/522 3800

Fax: +86/871/522 3800

Email: nhtan@mail.kib.ac.cn