Pharmacopsychiatry 2010; 43(6): 221-224
DOI: 10.1055/s-0030-1254090
Original Paper

© Georg Thieme Verlag KG Stuttgart · New York

Low Treatment Adherence with Antipsychotics is Associated with Relapse in Psychotic Disorders within Six Months after Discharge

W. Laan1 , Y. van der Does1 , B. Sezgi2 , H. M. Smeets1 , J. J. Stolker2 , 3 , 4 , N. J. de Wit1 , E. R. Heerdink2 , 3
  • 1Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
  • 2Division Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands
  • 3Altrecht Institute for Mental Health Care, Den Dolder, The Netherlands
  • 4Currently employed by Arkin, Institute for Mental Health Care, Amsterdam, The Netherlands
Further Information

Publication History

received 23.10.2009 revised 27.01.2010

accepted 08.03.2010

Publication Date:
25 May 2010 (eFirst)


Objective: The aim of this study was to assess the association between treatment adherence with antipsychotics and schizophrenia relapse on a continuous scale.

Method: A cohort study with a total of 477 patients with schizophrenia who were recently discharged from an inpatient clinic was performed.

Results: In the 160 people who relapsed within the six months after discharge the average medication possession ratio was 0.50. This was 0.59 in the 317 persons who were not readmitted. The resulting hazard ratio for the medication possession ratio on relapse risk was 0.60 (95% confidence interval: 0.42–0.88).

Conclusion: The found hazard ratio indicates that the risk of relapse is substantially decreased when a patient is properly adherent to the antipsychotic therapy that was prescribed at the inpatient clinic.



W. Laan, PhD 

Julius Centre for Health

Sciences and Primary Care

University Medical Centre


PO Box 85500

3508 GA Utrecht

The Netherlands

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