Planta Med 2011; 77(9): 955-957
DOI: 10.1055/s-0030-1250665
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

New Sesquiterpene Lactones from Glechoma hederacea L. and Their Cytotoxic Effects on Human Cancer Cell Lines

JinPyo Kim1 , IkSoo Lee2 , DoThi Ha1 , JeongJu Seo3 , ByungSun Min4 , IckDong Yoo2 , KiHwan Bae1
  • 1College of Pharmacy, Chungnam National University, Daejeon, Korea
  • 2Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
  • 3School of Medicine and Clinical Trial Center, Kyungpook National University Hospital, Daegu, Korea
  • 4College of Pharmacy, Catholic University of Daegu, Kyungbook, Korea
Further Information

Publication History

received August 9, 2010 revised November 26, 2010

accepted December 6, 2010

Publication Date:
17 January 2011 (online)


Three new sesquiterpene lactones, 1α,10β-epoxy-4-hydroxy-glechoma-5-en-olide (1), 1β,10α-epoxy-4,8-dihydroxy-glechoma-5-en-olide (2), and 1β,10α;4α,5β-diepoxy-8-methoxy-glechoman-8α,12-olide (3), were isolated from the whole plant of Glechoma hederacea, together with four known sesquiterpene lactones. The structures of the three new sesquiterpene lactones were determined by spectroscopic evidence. Cytotoxic effects of the isolated compounds were examined against MDA‐MB‐231 (breast), HCT116 (colon), SW620 (colon), and DU145 (prostate) human cancer cell lines.


Prof. Dr. KiHwan Bae

College of Pharmacy
Chungnam National University

Gung-dong 220, Yuseong-gu

Daejeon 305-764


Phone: +82 4 28 21 59 25

Fax: +82 4 28 23 65 66