A Unique Issue in the Standardization of Chinese Materia Medica: Processing

Abstract

Processing of Chinese Materia Medica (CMM) is a pharmaceutical technique to fulfill the different requirements of therapy, dispensing and making preparations according to traditional Chinese medicine theory. The aims of processing are to enhance the efficacy and/or reduce the toxicity of crude drugs. Those processed products are named as decoction pieces, which are used in clinics. Therefore, there is a close relationship between processing, safety, and efficacy of Chinese medicines. Some toxicity or side effects are caused by improper processing methods and some are due to improper combination of herbal mixtures. Standardization of processing methods for Chinese herbs is as important as authentication to maintain their quality and ensure their safe use. The objective of this paper is to review the literature covering the current situation and problems of CMM processing as well as recent progress in research in this area. A summary of the most urgent work needed is proposed.

processing - Chinese Materia Medica - decoction pieces - standardization

References

• 1 Zhao Z Z, Hu Y N, Liang Z T, Yuen J P S, Jiang Z H, Leung K S Y. Authentication is fundamental for standardization of Chinese medicines.  Planta Med. 2006;  72 865-874
• 2 State Pharmacopoeia Committee .Pharmacopoeia of the People's Republic of China (2010 Edition). Beijing; China Medical Science and Technology Press 2010
• 3 Society of Japanese Pharmacopoeia .Japanese Pharamacopoeia, 15th edition. Tokyo; Yakuji Nippo, Ltd. 2006
• 4 British pharmacopoeia commission .British Pharmacopoeia 2007. London; The Stationery Office on Behalf of the Medicines and Healthcare Products Regulatory Agency 2006
• 5 European pharmacopoeia commission .European Pharmacopoeia, 6th edition. Strasbourg; The Directorate for the Quality of Medicines & Healthcare of the Council of Europe 2007
• 6 The United States Pharmacopeial Convention .The United States Pharmacopoeia/National Formulary. Rockville, MD; The United States Pharmacopeial Convention 2007
• 7 Zou J M, Wang L S. Analysis of the condition of processing of Chinese Materia Medica.  Chin Tradit Herb Drugs. 2005;  36 620-623
• 8 Chan T Y, Tomlinson B, Tse L K, Chan J C, Chan W W, Critchley J A. Aconitine poisoning due to Chinese herbal medicines: a review.  Vet Hum Toxicol. 1994;  36 452-455
• 9 Wang X T. The view on the history investigation of CMM processing.  Chin J Chin Mater Med. 1992;  17 211-212
• 10 Lei F, compiled by Shang Z J. Lei Gong Pao Zhi Lun. Hefei; Anhui Science and Technology Press 1991
• 11 Miao X W. Pao Zhi Da Fa. Beijing; China Book Store 1992
• 12 Zhang R. Xiu Shi Zhi Nan. Haikou; Hainan Press 2000
• 13 Li S Z. Bencao Gangmu. Beijing; People Health Press 1985
• 14 China. Administration of Health of Fujian province .The processing practice of Chinese crude drugs in Fujian province. Fuzhou; Fujian Science and Technology Press 1988
• 15 China. Administration of Health of Hunan province .The processing practice of Chinese crude drugs in Hunan province (1983 edition). Changsha; Hunan Science and Technology Press 2000
• 16 China. Administration of Food and Drug of the Guangxi Zhuang Autonomous Region .The processing practice of Chinese crude drugs in Guangxi Zhuang Autonomous Region. Nanjing; Guangxi Science and Technology Press 2007
• 17 China. Administration of Food and Drug of Anhui province .The processing practice of Chinese crude drugs in Anhui province. Hefei; Anhui Science and Technology Press 2006
• 18 Zhao Z Z. An illustrated Chinese Materia Medica in Hong Kong. English version. Hong Kong; Chung Hwa Book Co. 2004
• 19 Korea Food and Drug Administration .The Korean Pharmacopoeia, 8th edition. Seoul; Yakup Daily 2002
• 20 Vietnamese Pharmacopoeia Commission Ministry of Health of S. R. Vietnam .Pharmacopoeia Vietnamica, 3rd edition. Hanoi; Ministry of Health 2005
• 21 Wang X T. The data collection of Chinese Materia Medica processing in the past dynasties (Ancient part). Nanchang; Jiangxi Science and Technology Press 1998
• 22 Zhang X Z, Cai G H. Processing of Chinese Materia Medica. Taichung; China Medical College 1984
• 23 Zheng J S, Qiu J. Preliminary study on the new appearing of “Buyi Leigong Paozhi Bianlian”.  Chin Pharmacol J. 2004;  39 389-391
• 24 Wang Q, Liu R X, Guo H Z, Zhu Z N, Bi K S, Guo D A. Study on influence of processing methods on chemical constituents in Radix Paeoniae Alba.  Chin J Chin Mater Med. 2006;  31 1418-1421
• 25 Xu L Y, Weng D H, Li X, Wang S, Luo K. The influences of processing methods on the contents of magnolol and honokiol.  J Chin Mater Med. 2007;  30 641-642
• 26 Feng H P, Yang Z L, Hu Y Z. Chromatographic studies on fingerprints of Cortex Magnoliae officinalis and their processed products by HPLC-DAD-MS.  Chin Tradit Pat Med. 2007;  29 84-88
• 27 Ding X, Cai B C. The comparative study on the contents of active constituents in Cornus officinalis before and after being processed.  Chin Tradit Pat Med. 2006;  28 1597-1600
• 28 Ding X, Zhu F S, Yu Z L, Dong L N, Cai B C. Comparative study on contents of amino acid and major and trace elements in Cornus officinalis before and after being processed.  J Chin Mater Med. 2007;  30 396-398
• 29 Dou Z Y, Sun W, Tian L L, Zhang M. Comparing the contents of three active components in raw materials and different processed products of Rhizoma Corydalis by HPLC method.  J Chin Mater Med. 2007;  30 399-401
• 30 Jiang Z H, Xie Y, Zhou H, Wang J R, Liu Z Q, Wong Y F, Cai X, Xu H X, Liu L. Quantification of aconitum alkaloids in aconite roots by a modified RP-HPLC method.  Phytochem Anal. 2005;  16 415-421
• 31 Wu W, Liang Z T, Zhao Z Z, Cai Z. Direct analysis of alkaloid profiling in plant tissue by using matrix-assisted laser desorption/ionization mass spectrometry.  J Mass Spectrom. 2007;  42 58-69
• 32 Lu G H, Dong Z Q, Wang Q, Qian G S, Huang W H, Jiang Z H, Leung K S Y, Zhao Z Z. Toxicity assessment of nine types of decoction pieces from the daughter root of Aconitum carmichaeli (Fuzi) based on chemical analysis of diester diterpenoid alkaloids.  Planta Med. 2010;  76 825-830
• 33 Choi Y H, Sohn Y M, Kim C Y, Oh K Y, Kim J. Analysis of strychnine from detoxified strychnos nux-vomica seeds using liquid chromatography-electrospray mass spectrometry.  J Ethnopharmacol. 2004;  93 109-112
• 34 Liu Z L, Song Z Q, Zhang L, Li S L. Influence of process methods on contents of chemical component Radix Polygoni Multiflori.  Chin J Chin Mater Med. 2005;  30 336-340
• 35 Liang Z T, Chen H B, Yu Z L, Zhao Z Z. Comparative analysis of raw and processed Radix Polygoni Multiflori by high performance liquid chromatographic fingerprint and mass spectrometry.  Chin Med. 2010;  5 29-36
• 36 Fan D L, Liao Q W, Yan D, Xiao X H, Ma X J. Study on alkaloid of differently processed Coptis chinensis.  Pharm J Chin PLA. 2006;  22 276-279
• 37 Ren S L, Zhang N N, Liu Z L, Liu J L, Liu J. Study on chemical changes of whole constituents in the preparing process of Kansui root.  J Chin Mater Med. 2007;  30 639-640
• 38 Yuan Z M, Wang J, Lu J, Jia T Z. Comparing analysis of components in volatile oils of nutmeg and prepared nutmeg by GC-MS.  Chin J Chin Mater Med. 2006;  31 737-739
• 39 Shim S H, Kim J S, Kang S S. Norditerpenoid alkaloids from the processed tubers of Aconitum carmichaeli.  Chem Pharm Bull. 2003;  51 999-1002
• 40 Shim S H, Lee S Y, Kim J S, Son K H, Kang S S. Norditerpenoid alkaloids and other components from the processed tubers of Aconitum carmichaeli.  Arch Pharm Res. 2005;  28 1239-1243
• 41 Wang H P, Wang J M, Wang D N. Studies on fingerprint of Suanzaoren and their processing products.  Chin Pharmacol J. 2006;  41 173-175
• 42 Li G H, Dong Q N, Sun F J, Fu Z W, Cai A M, Lu M Y, Yang S B. The influences of different processing methods on the toxicity and effect of relieving cough and asthma of Semen Armeniacae Amarum.  Chin J Chin Mater Med. 2007;  32 1247-1250
• 43 Gao Q, Xu H Q, Chen J W, Zhang J. Liver-protective and bowel-lubricating and defecation-promoting effects of crude and processed Semen Cassiae.  Tradit Chin Drug Res Clin Pharmacol. 2007;  18 194-196
• 44 Wu T, Chen Z J, Hu Y J, Xiu Y F, Cheng X M. Experimental study on phlegm-resolving action of different prepared products of Radix Asteris.  Acta Univ Tradit Med Sin Pharmacol Shanghai. 2006;  20 55-57
• 45 Jiang X, Li L, Wang W H, Wang J H, Gao H M, Wang Z M. Toxicologically studies of raw Radix Aristolochiae and its processed product.  Chin Remed Clin. 2006;  6 485-487
• 46 Wang J H, Wang Z M, Jiang X, Xue B Y, Li C Y. Pharmacodynamic and toxicological comparative study of crude and processed Radix Aristolochice.  Chin J Chin Mater Med. 2007;  32 428-433
• 47 Gong Q F, Zhou D G, Zhang D F, Chen Q. Experimental study on acute toxicity of Semen Strychni and its processed products.  Jiangxi Coll Tradit Chin Med. 2007;  19 47-48
• 48 Cai B, Nagasawa T, Kadota S, Hattori M, Namba T, Kuraishi Y. Processing of nux vomica. VII. Antinociceptive effects of crude alkaloids from the processed and unprocessed seeds of Strychnos nux-vomica in mice.  Biol Pharm Bull. 1996;  19 127-131
• 49 Liou S S, Liu I M, Lai M C, Cheng J T. Comparison of the antinociceptive action of crude Fuzei, the root of Aconitum, and its processed products.  J Ethnopharmacol. 2005;  99 379-383
• 50 Wang J, van der Heijden R, Spruit S, Hankermeier T, Chan K, van der Greef J, Xu G, Wang M. Quality and safety of Chinese herbal medicines guided by a systems biology perspective.  J Ethnopharmacol. 2009;  126 31-41
• 51 Lu X E, Xu L Y, Wang H W, Li X. Study on processing techniques of Cyperus rotundus.  Northwest Pharmacol J. 2007;  22 58-59
• 52 Yang Y, Wen Y J, Wang J M, Tian R T. Processing method and HPLC fingerprint of charred Radix Scutellariae.  Chin J Chin Mater Med. 2007;  32 1518-1521
• 53 Lu T L, Yin F X, Mao C Q, Ma X F, Su D. Study on the procedure of processing Fructus Schisandrae Chinensis.  Chin Tradit Pat Med. 2007;  29 543-545
• 54 Ding A W, Zhu C J. Study on the processing technology and quality standard of Cacumen Platycladi Orientalis.  J Chin Mater Med. 1994;  17 24-27
• 55 Ding A W, Zhang L, Wu L W, Kong L D, Sheng R C. Study on the processing technology and quality standard of Herba Cirsii Japonici.  J Chin Mater Med. 1998;  21 560-562
• 56 Wu L Y, Wang X T, Mao S J, Chen L P. Study on the improvement of processing technology of Rhizoma Arisaemae.  Chin J Chin Mater Med. 1997;  22 18-20
• 57 Chen J M (Ming dynasty). Bencao Mengquan. Beijing; People's Health Press 1988
• 58 Xu B H, Tian N. Application far-infrared oven to improve the processing quality of crude drugs.  Heilongjiang Med J. 1996;  9 35-36
• 59 Li A G, Zhu W X, Chen F, Miao J W, Zhu Z B. Technology study on the processing Radix Glycyrrhizae with honey by far-infrared oven.  Lishizhen Med Mater Med Res. 2006;  17 336-337
• 60 Li R N, Yuan S T. The effects of carbonizing temperature and heating time on HPLC fingerprints of Flos sophorae.  Chin Tradit Pat Med. 2006;  28 978-981
• 61 Shen L X, Li Y F, Feng X. The optimization of new processing technology of Cortex Eucommiae.  Chin J Mod Appl Pharm. 2000;  7 446-448
• 62 Guo Y H, Jia T Z, Lin G H. Study on Micro-wave processed of Psoralea corylifolia with uniform and regression analysis.  Chin J Chin Mater Med. 2007;  32 1167-1170
• 63 Yu Y M, Song C Y, Jia T Z. Quality standard of processed products of Rhizoma Atractylodis Macrocephalae.  Chin Tradit Patent Med. 2005;  27 669-672