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Planta Med 2010; 76(17): 1987-1996
DOI: 10.1055/s-0030-1250520
DOI: 10.1055/s-0030-1250520
Traditional Chinese Medicine
Reviews© Georg Thieme Verlag KG Stuttgart · New York
Application of Mid-Infrared Spectroscopy in the Quality Control of Traditional Chinese Medicines
Weitere Informationen
Publikationsverlauf
received February 11, 2010
revised Sept. 29, 2010
accepted October 7, 2010
Publikationsdatum:
03. November 2010 (online)
Abstract
Chinese herbal medicines are often referred to as Chinese materia medica (CMM). Composite formulae containing mixtures of CMM are prescribed for treatment and prevention of diseases in the practice of traditional Chinese medicine (TCM). Some of the well-known CMM formulae (Fufang in Chinese) are manufactured and marketed as proprietary Chinese medicines (PCM). Quality assessment and assurance of these products are difficult; they are a challenging task. Mid-infrared spectroscopy, a classic molecular structure analysis method, has been innovatively applied in the quality control of TCM, and has gained significant impact and advancement in analytical fields. Infrared fingerprinting features appear particularly suitable for the identification of multicomponent matrices in samples whose chemical integrity has not been altered or destroyed because no extraction procedure is needed. This review summarizes and gives an overall view on the application of mid-infrared and two-dimensional correlation infrared (2D‐IR) spectroscopy as well as chemometric techniques in the identification of CMM, investigation of TCM processing procedures, and analysis of herb extracts and preparations.
Key words
traditional Chinese medicine - quality control - mid‐infrared spectroscopy - two‐dimensional correlation infrared spectroscopy - chemometric techniques
References
- 1 Liang Y Z, Xie P S, Chan K. Quality control of herbal medicines. J Chromatogr B. 2004; 812 53-70
- 2 Sun S Q, Zhang X, Qin Z, Hu X Y. Direct determination of raw plant drugs by FTIR. Spectrosc Spectral Anal. 1999; 19 542-545
- 3 Sun S Q, Yu J Y, Hu X Y. New researches in the direct determination of Chinese traditional drugs with molecular spectroscopy. Spectrosc Spectral Anal. 1999; 19 841-843
- 4 Sun S Q, Zhou Q, Yu J Y, Hu X Y. The latest development of the research on Chinese medicine by molecular vibrational spectroscopy. Spectrosc Spectral Anal. 2000; 20 199-202
- 5 Liu H, Sun S Q. Application and progress of molecular vibrational spectrum in traditional Chinese medicine modernization. Med Instrum. 2005; 5 6-10
- 6 Sun S Q, Zhou Q, Qin Z. Atlas of two-dimensional correlation infrared spectroscopy for traditional Chinese
medicine identification. Beijing; Chemical Industry Press 2003
Reference Ris Wihthout Link
- 7 Noda I. Two-dimensional infrared spectroscopy of synthetic and biopolymers. Bull Am Phys Soc. 1986; 31 520
- 8 Noda I. Generalized two-dimensional infrared spectroscopy. J Am Chem Soc. 1989; 111 8116-8118
- 9 Noda I. Generalized two-dimensional correlation method applicable to infrared, Raman, and other types of spectroscopy. Appl Spectrosc. 1993; 47 1329-1336
- 10 Li Y M, Sun S Q, Zhou Q, Tao J X, Noda I. Study of traditional Chinese animal drugs using FT-IR and 2D-IR correlation spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc. 2006; 63 565-573
- 11 Wang L Q, Li Y M, Zhang L P, Xiao H X, Zhou Q, Sun S Q. Analysis and characterization of fingerprint infrared spectra for ecology-planted Coptis chinensis. Spectrosc Spectral Anal. 2006; 26 1061-1066
- 12 Pei L K, Sun S Q, Guo B L, Huang W H, Xiao P G. Fast quality control of Herba Epimedii by using Fourier transform infrared spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc. 2008; 70 258-264
- 13 Cheung Y M, Zhou Q, Guo B L, Sun S Q. Identifying the characteristics of FTIR spectra of Herba Epimedii Icariin via wavelet analysis and RBF neural network. Spectrosc Spectral Anal. 2009; 29 1830-1834
- 14 Cao F, Zhou Q, Sun S Q. Study on the identification of standard and false Tianma by two-dimensional infrared correlation spectroscopy. Med Instrum. 2002; 4 19-21
- 15 Zhou Q, Li J, Liu J, Huang H, Sun S Q. Two-dimensional correlation infrared spectroscopy of standard and false Dahuang. Chin J Anal Chem. 2003; 31 1058-1061
- 16 Sun S Q, Zhou Q, Liu J, Huang H. Study on the identification of standard and false Banxia by two-dimensional infrared correlation spectroscopy. Spectrosc Spectral Anal. 2004; 24 427-430
- 17 Xu C H, Zhou Q, Sun S Q, Wang B Q. The identification of Ejiao by two dimensional correlation infrared spectroscopy. Chin J Anal Chem. 2005; 33 221-224
- 18 Ayiguli T, Zhou Q, Dong X O, Sun S Q. Study on the identification of standard and false Gancao by Fourier transform infrared spectroscopy. Spectrosc Spectral Anal. 2006; 26 1238-1241
- 19 Zhou J, Sun J Y, Xu S Y, Zhou Q, Sun S Q. Study on the identification of Illicium vatum Hook. f. and Illicium lanceolatum A. C. Smith by multi-steps infrared macro-fingerprint method. Spectrosc Spectral Anal. 2008; 28 2864-2867
- 20 Huang D L, Sun S Q, Xu Y Q, Chen X K. Analysis and identification of Dangshen and its counterfeit Yeguanmen by Fourier transform infrared spectroscopy. Med Instrum. 2008; 5 22-25
- 21 Cai F, Sun S Q, Yan W R, Niu S J, Li X E. Identification and analysis of genuine and false Flos Rosae Rugosae by FTIR and 2D correlation IR spectroscopy. Spectrosc Spectral Anal. 2009; 29 2429-2433
- 22 Chen J, Sun S Q, Xu R, Liu Y G, Yu J, Liu T N, Li J Q. Identification of Cistanche deserticola from Boschniakla rossica and Cynomorium songaricum using FTIR and two-dimensional correlation IR spectroscopy. Spectrosc Spectral Anal. 2009; 29 1502-1507
- 23 Yang P, Song P, Sun S Q, Zhou Q, Feng S, Tao J X. Differentiation and quality estimation of Cordyceps with infrared spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc. 2009; 74 983-990
- 24 Cheng Z F, Xu R, Cheng C G. Study on identification of Gastrodia elata BI. by Fourier self-deconvolution infrared spectroscopy. Spectrosc Spectral Anal. 2007; 27 1719-1722
- 25 Cheng C G, Ying T K. Quality control of Corydalis yanhusuo W. T. Wang by second derivative FTIR spectroscopy combined with statistics. Spectrosc Spectral Anal. 2005; 25 36-38
- 26 Cheng C G, Sun C R, Pan Y J. Direct identification of Ophiogon japonicus (Thunb.)Ker-Gawl. from its confusable varieties by second derivative FTIR spectroscopy combined with statistics. Spectrosc Spectral Anal. 2004; 24 1055-1059
- 27 Jin W Y, Cheng C G, Wu X H. Identification of Rhizoma Atractylodes based on FTIR spectra and radial basis function network. Spectrosc Spectral Anal. 2006; 26 2210-2213
- 28 Ma S M, Liu S D, Zhang Z Y, Fan G Q. Radial basis function networks and IR spectrometry applied for identification of official Rhubarb samples. Spectrosc Spectral Anal. 2005; 25 874-877
- 29 Han M X, Zhou Q, Li Q H, Sun S Q. Identification of three-step IR spectra of Radix Puerariae from different habitats. Spectrosc Spectral Anal. 2009; 29 1851-1855
- 30 Hua R, Sun S Q, Zhou Q, Noda I, Wang B Q. Discrimination of Fritillary according to geographical origin with Fourier transform infrared spectroscopy and two-dimensional correlation IR spectroscopy. J Pharm Biomed Anal. 2003; 33 199-209
- 31 Li Y M, Sun S Q, Zhou Q, Qin Z, Tao J X, Wang J, Fang X. Identification of American ginseng from different regions using FT-IR and two-dimensional correlation IR spectroscopy. Vib Spectrosc. 2004; 36 227-232
- 32 Zhou X, Sun S Q, Huang Q H. Identification of Pericarpium Citri Reticulatae from different regions using FTIR. Spectrosc Spectral Anal. 2007; 27 2453-2455
- 33 Sun S Q, Yuan Z M, Bai Y. Identify the genuine of Shanyao (Dioscorea opposite Thunb.) by FTIR combined with computer aided analysis. Comput Appl Chem. 2002; 19 77-80
- 34 Xu Y Q, Sun S Q, Yuan Z M, Bai Y. Discrimination of trueborn tuber dioscoreae by fingerprint infrared spectra and principal component analysis. Chin J Anal Chem. 2002; 30 1231-1233
- 35 Sun S Q, Tang J M, Yuan Z M, Bai Y. FTIR and classification study on trueborn tuber dioscoreae samples. Spectrosc Spectral Anal. 2003; 23 258-261
- 36 Zhou Q, Sun S Q, Leung H W. FTIR and classification study on Gouqi from different cultural areas. Spectrosc Spectral Anal. 2003; 23 509-511
- 37 Liu S H, Zhang X G, Zhou Q, Sun S Q. Use of FTIR and pattern recognition to determine geographical origins of Chinese medical herbs. Spectrosc Spectral Anal. 2005; 25 878-881
- 38 Xu Y Q, Sun S Q, Feng X F, Hu S L. Quick identification of Skullcaps in different geographical origins using clustering analysis method and infrared fingerprint spectra. Spectrosc Spectral Anal. 2003; 23 502-505
- 39 Xu Y Q, Huang H, Zhou Q, Zhou H T, Hu S L, Sun S Q. The application of fingerprint infrared spectra and clustering analysis in the discrimination of geographical origin of Paeonia lactiflora Pall. Chin J Anal Chem. 2003; 31 5-9
- 40 Wang F L, Zhou J K, Wu J, Yu L, Sun S Q. Study on the identification of cultivated and wilding Danshen by multi-steps infrared macro-fingerprint method. Med Instrum. 2006; 5 18-20
- 41 Liu D, Li Y G, Xu H, Sun S Q, Wang Z T. Differentiation of the root of Cultivated Ginseng, Mountain Cultivated Ginseng and Mountain Wild Ginseng using FT-IR and two-dimensional correlation IR spectroscopy. J Mol Struct. 2008; 883 228-235
- 42 Liu G, Dong Q, Yu F, Liu J H, Sun S Z. Identification of Gastrodia elata Blume by Fourier transform infrared spectroscopy. Spectrosc Spectral Anal. 2004; 24 308-310
- 43 Dong B, Sun S Q, Zhou H T, Hu S L. Rapid and undamaged determination of Chishao by Fourier-transform infrared spectroscopy and clustering analysis. Spectrosc Spectral Anal. 2002; 22 232-234
- 44 Dong B, Sun S Q, Qin Z, Zhou H T, Hu S L. Rapid and undamaged determination of Chishao by Fourier-transform infrared spectroscopy and clustering analysis. Comput Appl Chem. 2002; 19 89-92
- 45 Xu R, Sun S Q, Liu Y G, Yu J, Zhou F, Liu T N, Chen J, Chen S L. Rapid and undamaged determination of Cistanche deserticola by Fourier-transform infrared spectroscopy and clustering analysis. Spectrosc Spectral Anal. 2009; 29 1860-1863
- 46 Xu Y Q, Zhou Q, Sun S Q, Cai S Q. Recognition of three classes of Skullcaps by FTIR spectroscopy combined with artificial neural networks. Spectrosc Spectral Anal. 2002; 22 945-948
- 47 Huang H, Sun S Q, Xu J W, Wang Z. Novel application of FTIR in medical herb chemotaxonomy. Spectrosc Spectral Anal. 2003; 23 253-257
- 48 Lu G H, Zhou Q, Sun S Q, Leung K S Y, Zhang H, Zhao Z Z. Differentiation of Asian ginseng, American ginseng and Notoginseng by Fourier transform infrared spectroscopy combined with two-dimensional correlation infrared spectroscopy. J Mol Struct. 2008; 883 91-98
- 49 Wang Z, Sun S Q, Li X B, Zhou Q, Lin L, Du D G. Direct determination of Rhizoma Cimicifuga by FTIR spectroscopy. Spectrosc Spectral Anal. 2001; 21 311-313
- 50 Peng Y, Sun S Q, Zhao Z Z, Leung H W. A rapid method for identification of genus Lycium by FTIR spectroscopy. Spectrosc Spectral Anal. 2004; 24 679-681
- 51 Pei L K, Guo B L, Sun S Q, Huang W H. Study on the identification of some species of Herba Epimedii with FTIR. Spectrosc Spectral Anal. 2008; 28 55-60
- 52 Chen J B, Zhou Q, Noda I, Sun S Q. Quantitative classification of two-dimensional correlation spectra. Appl Spectrosc. 2009; 63 920-925
- 53 Chen J B, Zhou Q, Noda I, Sun S Q. Discrimination of different genera Astragalus samples via quantitative symmetry analysis of two-dimensional hetero correlation spectra. Anal Chim Acta. 2009; 649 106-110
- 54 Lu G H, Sun S Q, Leung H W, Chan K K C. Study on the identification of Dangguitou and Dangguiwei by two-dimensional infrared correlation spectroscopy. Spectrosc Spectral Anal. 2004; 24 311-314
- 55 Jin Z X, Xu S Y, Sun S Q, Zhou Q. Analysis of Acanthopanax senticosus Harms for different parts using Fourier transform infrared spectroscopy. Spectrosc Spectral Anal. 2008; 28 2859-2863
- 56 Xu R, Sun S Q, Liu Y G, Chen J, Chen S L, Zhou F. Analysis and evaluation of different radial part of Cistanche deserticola by Fourier transform infrared spectroscopy and two-dimensional infrared correlation spectroscopy. Chin J Anal Chem. 2009; 37 221-226
- 57 Hong Q H, Cheng Z F, Cheng C G. Application of FTIR spectroscopy to the analysis of quality mensuration of Paeonia lactiflora Pall. from native habitat. Spectrosc Spectral Anal. 2006; 26 1610-1613
- 58 Zhan D Q, Cheung Y M, Sun S Q. Wavelet-transform based identification of ginseng of different ages using two-dimensional infrared correlation spectroscopy. Spectrosc Spectral Anal. 2007; 27 1497-1501
- 59 Zhou X, Sun S Q, Huang Q H. Identification of Pericarpium Citri Reticulatae from different years using FTIR. Spectrosc Spectral Anal. 2008; 28 72-74
- 60 Sun S Q, Wang M Q, Leung H W, Yeung H W. A rapid method for the identification of four different features of Gouqizi by FTIR spectrometry. Spectrosc Spectral Anal. 2001; 21 787-789
- 61 Liu Y, Wang J Q, Liu S H, Sun S Q. Two-dimensional correlation infrared spectroscopy applied to analyzing and identifying the Radix Paeoniae Alba medicinal materials. J Mol Struct. 2008; 883 137-141
- 62 Yu L, Sun S Q, Fan K F, Zhou Q, Noda I. Research on processing medicinal herbs with multi-steps infrared macro-fingerprint method. Spectrochim Acta A Mol Biomol Spectrosc. 2005; 62 22-29
- 63 Yu L, Sun S Q, Zhou Q, Qin Z. Research on parching procedure of white mustard seed with Fourier transform infrared spectroscopy and two-dimensional IR correlation spectroscopy. Spectrosc Spectral Anal. 2006; 26 2181-2185
- 64 Tang J M, Xian D, Sun S Q. Study on Radix Aconiti and Radix Aconiti Preparata by two-dimensional infrared correlation spectroscopy. Med Instrum. 2005; 3 27-30
- 65 Wang C L, Wen J M, Cheng T, Jiang K W, Sun S Q, Tu Y. Study on Aconitum kusnezoffii Reichb. and its processed products by 2D-IR correlation spectroscopy. Spectrosc Spectral Anal. 2009; 29 1498-1501
- 66 Sun S Q, Zhou Q, Leung H W. Study on Paofupian, Heishunpian and Baifupian by two-dimensional infrared correlation spectroscopy. Spectrosc Spectral Anal. 2003; 23 1082-1085
- 67 Bao H J, An H, Bai Y, Sun S Q. The analysis and identification of Chrysanthemum and processed Chrysanthemum by IR and second-order derivative spectroscopy. Med Instrum. 2004; 5 26-28
- 68 Xu C H, Sun S Q, Guo C Q, Zhou Q, Tao J X, Noda I. Multi-steps infrared macro-fingerprint analysis for thermal processing of Fructus Viticis. Vib Spectrosc. 2006; 41 118-125
- 69 Liu H X, Sun S Q, Lv G H, Chan K K C. Study on Angelica and its different extracts by Fourier transform infrared spectroscopy and two-dimensional correlation IR spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc. 2006; 64 321-326
- 70 Liu H X, Sun S Q, Lv G H, Liang X Y. Discrimination of extracted lipophilic constituents of Angelica with multi-steps infrared macro-fingerprint method. Vib Spectrosc. 2006; 40 202-208
- 71 Liu H X, Zhou Q, Sun S Q, Bao H J. Discrimination of different Chrysanthemum with Fourier transform infrared spectroscopy. J Mol Struct. 2008; 883 38-47
- 72 Wu Y W, Xiao X H, Sun S Q, Liu H X. Study on traditional Chinese medicine extracts of Rhizoma Coptidis by FTIR spectroscopy. Spectrosc Spectral Anal. 2009; 29 93-96
- 73 Huang H, Jing L, Qin Z, Zhou Q, Sun S Q. The application of Fourier transform infrared spectroscopy on the quality control of traditional Chinese medicine formula particles. Chin J Anal Chem. 2003; 31 828-832
- 74 Zhou Q, Li J, Sun S Q, Liang X Y. Rapid identification of traditional Chinese medicine formula particles by Fourier transform infrared spectroscopy. Chin J Anal Chem. 2003; 31 292-295
- 75 Tang J M, Sun S Q, Yuan Z M, Qin Z. Study on the rapid and nondestructive identification of TCM formula particles by FTIR. Spectrosc Spectral Anal. 2004; 24 554-556
- 76 Wu J, Sun S Q, Zhou Q, Yu L. Study on rapid and nondestructive analysis of Danshen formula particles by FTIR. Spectrosc Spectral Anal. 2007; 27 1535-1538
- 77 Zuo L, Sun S Q, Tang J M. Two-dimensional correlation analysis of FT-IR spectra for research on the thermal stability of the Qingkailing injection. Comput Appl Chem. 2002; 19 95-98
- 78 Zuo L, Sun S Q, Zhou Q, Tao J X, Noda I. 2D-IR correlation analysis of deteriorative process of traditional Chinese medicine ‘Qing Kai Ling injection. J Pharm Biomed Anal. 2003; 30 1491-1498
- 79 Zhou Q, Sun S Q, Zuo L. Study on traditional Chinese medicine ‘Qing Kai Ling injections from different manufactures by 2D IR correlation spectroscopy. Vib Spectrosc. 2004; 36 207-212
- 80 Chen J B, Zhou Q, Sun S Q, Yu L, Xu K Y. Study on quality control of traditional Chinese medicine ginseng injection with Fourier transform infrared spectroscopy. Spectrosc Spectral Anal. 2007; 27 1493-1496
- 81 Zhang P, Sun S Q, Zhou Q, Xu K Y. Study on quality control of safflower injection and wild chrysanthemum injection with Fourier transform infrared spectroscopy. Spectrosc Spectral Anal. 2007; 27 1539-1542
- 82 Yan S, Xu M L, Tu Y, Li H F, Sun S Q. Qualitative and quantitative analysis of Shuanghuanglian fenzhenji by FTIR. Spectrosc Spectral Anal. 2009; 29 1558-1561
- 83 Wu Y W, Sun S Q, Zhou Q, Tao J X, Noda I. Volatility-dependent 2D IR correlation analysis of traditional Chinese medicine ‘Red Flower Oil preparation from different manufacturers. J Mol Struct. 2008; 882 107-115
- 84 Wu Y W, Sun S Q, Zhou Q, Leung H W. Fourier transform mid-infrared (MIR) and near-infrared (NIR) spectroscopy for rapid quality assessment of Chinese medicine preparation Honghua Oil. J Pharm Biomed Anal. 2008; 46 498-504
- 85 Chan K. Chinese medicinal materials and their interface with Western medical concepts. J Ethnopharmacol. 2005; 96 1-18
Prof. Suqin Sun
Department of Chemistry
Tsinghua University
Beijing 100084
China
Telefon: +86 10 62 78 76 61
Fax: +86 10 62 78 24 85
eMail: sunsq@mail.chem.tsinghua.edu.cn
Prof. Guanghua Lu
School of Pharmacy
Chengdu University of Traditional Chinese Medicine
Chengdu 611137
China
Telefon: +86 28 61 80 02 31
eMail: luguanghua@hotmail.com