Abstract
Chinese herbal medicines are often referred to as Chinese materia medica (CMM). Composite
formulae containing mixtures of CMM are prescribed for treatment and prevention of
diseases in the practice of traditional Chinese medicine (TCM). Some of the well-known
CMM formulae (Fufang in Chinese) are manufactured and marketed as proprietary Chinese medicines (PCM).
Quality assessment and assurance of these products are difficult; they are a challenging
task. Mid-infrared spectroscopy, a classic molecular structure analysis method, has
been innovatively applied in the quality control of TCM, and has gained significant
impact and advancement in analytical fields. Infrared fingerprinting features appear
particularly suitable for the identification of multicomponent matrices in samples
whose chemical integrity has not been altered or destroyed because no extraction procedure
is needed. This review summarizes and gives an overall view on the application of
mid-infrared and two-dimensional correlation infrared (2D‐IR) spectroscopy as well
as chemometric techniques in the identification of CMM, investigation of TCM processing
procedures, and analysis of herb extracts and preparations.
Key words
traditional Chinese medicine - quality control - mid‐infrared spectroscopy - two‐dimensional
correlation infrared spectroscopy - chemometric techniques
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Prof. Suqin Sun
Department of Chemistry Tsinghua University
Beijing 100084
China
Telefon: +86 10 62 78 76 61
Fax: +86 10 62 78 24 85
eMail: sunsq@mail.chem.tsinghua.edu.cn
Prof. Guanghua Lu
School of Pharmacy Chengdu University of Traditional Chinese Medicine
Chengdu 611137
China
Telefon: +86 28 61 80 02 31
eMail: luguanghua@hotmail.com