Planta Med 2010; 76(16): 1874-1876
DOI: 10.1055/s-0030-1250030
Pharmacology
Letters
© Georg Thieme Verlag KG Stuttgart · New York

In Vitro Anti-influenza Viral Activities of Stilbenoids from the Lianas of Gnetum pendulum

Ai-Lin Liu1 , Fan Yang1 , Mian Zhu1 , Dan Zhou1 , Mao Lin2 , Simon Ming-Yuen Lee3 , Yi-Tao Wang3 , Guan-Hua Du1
  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • 2Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Beijing, China
  • 3Institute of Chinese Medical Sciences, University of Macau, Macao, China
Further Information

Publication History

received March 6, 2010 revised April 7, 2010

accepted May 9, 2010

Publication Date:
10 June 2010 (online)

Abstract

The anti-influenza viral activities of six stilbenoids from the lianas of Gnetum pendulum C. Y. Cheng were evaluated with two different assays, neuraminidase (NA) activity assay and cytopathic effect (CPE) reduction assay. The NA assay results showed that all six stilbenoids exerted an NA inhibitory effect, while the CPE assay indicated that among them, isorhapontigenin (2), gnetupendin B (3), shegansu B (4), and gnetin D (6) exhibit significant in vitro anti-influenza viral activity in MDCK cells, with IC50 values from 0.67 to 11.99 µg/mL in comparison to the positive controls oseltamivir acid and ribavirin whose IC50 values were 0.040 and 5.54 µg/mL, respectively.

References

Dr. Simon Ming-Yuen Lee

Institute of Chinese Medical Sciences
University of Macau

Av. Padre Tomás Pereira S. J.

Taipa, Macao

China

Phone: +85 3 83 97 46 95

Fax: +85 38 44 13 58

Email: simonlee@umac.mo

Prof. Ai-Lin Liu, PhD

Institute of Materia Medica
Chinese Academy of Medical Sciences and Peking Union Medical College

1 Xian Nong Tan Street

100050 Beijing

China

Phone: +86 10 63 16 51 84

Fax: +86 10 63 16 51 84

Email: liuailin@imm.ac.cn

Prof. Dr. Guan-Hua Du

Institute of Materia Medica
Chinese Academy of Medical Sciences and Peking Union Medical College

Xian Nong Tan Street

100050 Beijing

China

Phone: +86 10 63 16 51 84

Fax: +86 10 63 01 77 57

Email: dugh@imm.ac.cn