Antihyperlipidemic Effect of Protodioscin, an Active Ingredient Isolated from the Rhizomes of Dioscorea nipponica

Tiejie Wang; Roy C. Y. Choi; Jun Li; Cathy W. C. Bi; Linquan Zang; Zhongbo Liu; Tina T. X. Dong; Kaishun Bi; Karl W. K. Tsim

doi:10.1055/s-0030-1249960

Planta Medica, Table of Contents

Planta Med 2010; 76(15): 1642-1646
DOI: 10.1055/s-0030-1249960

Pharmacology

Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Antihyperlipidemic Effect of Protodioscin, an Active Ingredient Isolated from the Rhizomes of Dioscorea nipponica

Tiejie Wang¹ ^, ⁴ , Roy C. Y. Choi⁴ , Jun Li¹ , Jun Li⁴ , Cathy W. C. Bi⁴ , Linquan Zang³ , Zhongbo Liu² , Tina T. X. Dong⁴ , Kaishun Bi² , Karl W. K. Tsim⁴

¹Shenzhen Institute for Drug Control, Shenzhen, PR China
²School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, PR China
³Department of Pharmacology, Pharmacy School of Guangdong Pharmaceutical University, Guangzhou, PR China
⁴Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, PR China

Abstract

Developing drugs against metabolic-related disorders, including obesity and hyperlipidemia, is of importance for human health. Here, a bioactive phytochemical, protodioscin, isolated from the rhizomes of Dioscorea nipponica (Rhizoma Dioscoreae Nipponicae), was identified for its anti-hyperlipidemic effect. In hyperlipidemic rats, the post-administration of protodioscin significantly reduced the time of blood coagulation. In addition, the blood levels of triglyceride, cholesterol, low-density and high-density lipoproteins were also changed accordingly. Taken together, this was the first report of an antihyperlipidemic effect of protodioscin. Its great availability in various vegetables and medicinal plants will be useful in developing health food supplement(s) and/or drug(s) against hyperlipidemia.

Key words

Dioscorea nipponica Makino - Disocorea L. - Dioscoreaeceae - protodoscin - hyperlipidemic

Full Text

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Prof. Dr. Karl W. K. Tsim

Department of Biology
The Hong Kong University of Science and Technology

Clear Water Bay Road, Kowloon Hong Kong

NIL Hong Kong

China

Phone: + 85 2 23 58 73 32

Fax: + 85 2 23 58 15 59

Email: botsim@ust.hk