Planta Med 2010; 76(15): 1755-1758
DOI: 10.1055/s-0030-1249926
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Steroids from Polyporus umbellatus

Ying-Yong Zhao1 , Xu Chao1 , Yongmin Zhang3 , Rui-Chao Lin1 , 2 , Wen-Ji Sun1
  • 1Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an, China
  • 2National Institute for the Control of Pharmaceutical and Biological Products, Beijing, China
  • 3Université Pierre & Marie Curie-Paris 6, Institut Parisien de Chimie Moléculaire, Paris, France
Further Information

Publication History

received July 29, 2009 revised March 5, 2010

accepted April 15, 2010

Publication Date:
10 May 2010 (online)

Abstract

The steroids ergone (1), (22E, 24R)-ergosta-7,22-dien-3β-ol (2), 5α,8α-epidioxy-(22E,24R) ‐ergosta-6,22-dien-3β-ol (3), ergosta-6,22-dien-3β,5α,6β-triol (4), and polyporusterone B (5) were isolated from Polyporus umbellatus by bioassay-guided approach. They showed potent anticancer activity against HepG2 cells. Ergone displayed remarkable anticancer activity against HepG2, Hep-2, and Hela cancer cells, of which HepG2 cells were the most sensitive. Furthermore, the cytotoxic effects of ergone on normal human cells (HUVEC) were smaller than on cancer cells. The results showed that ergone had more selective cytotoxic activity against cancer cells than against normal cells.

References

Prof. Wen-Ji Sun

Biomedicine Key Laboratory of Shaanxi Province
Northwest University

No. 229 Taibai North Road

Xi'an, Shaanxi 710069

China

Phone: + 86 29 88 30 45 69

Fax: + 86 29 88 30 43 68

Email: cxbml@nwu.edu.cn

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