Planta Med 2010; 76(15): 1654-1658
DOI: 10.1055/s-0030-1249860
Pharmacology
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Raspberry Ketone Increases Both Lipolysis and Fatty Acid Oxidation in 3T3-L1 Adipocytes

Kyoung Sik Park1
  • 1Nutrition & Functional Food Research Team, Korea Food & Drug Administration, Seoul, Korea
Further Information

Publication History

received Sept. 29, 2009 revised March 15, 2010

accepted April 1, 2010

Publication Date:
27 April 2010 (eFirst)

Abstract

Raspberry ketone (RK) is a natural phenolic compound of the red raspberry. The dietary administration of RK to male mice has been reported to prevent high-fat diet-induced elevation in body weight and to increase lipolysis in white adipocytes. To elucidate a possible mechanism for the antiobesity action of RK, its effects on the expression and the secretion of adiponectin, lipolysis, and fatty acid oxidation in 3T3-L1 were investigated. Treatment with 10 µM of RK increased lipolysis significantly in differentiated 3T3-L1 cells. An immunoassay showed that RK increased both the expression and the secretion of adiponectin, an adipocytokine mainly expressed and secreted by adipose tissue. In addition, treatment with 10 µM of RK increased the fatty acid oxidation and suppressed lipid accumulation in 3T3-L1 adipocytes. These findings suggest that RK holds great promise as an herbal medicine since its biological activities alter the lipid metabolism in 3T3-L1 adipocytes.

References

Kyoung Sik Park, Ph.D.

Nutrition & Functional Food Research Team
Korea Food & Drug Administration

194 Tongil-ro, Eunpyung-gu

Seoul 122–704

Korea

Phone: + 82 23 80 16 65

Fax: + 82 23 85 70 81

Email: parkks71@kfda.go.kr