Erfahrungsheilkunde 2012; 61(3): 167-170
DOI: 10.1055/s-0030-1248347
Herzinsuffizienz
© Karl F. Haug Verlag MVS Medizinverlage Stuttgart GmbH & Co. KG

Herzinsuffizienz und Mikronährstoffe

Hans-Peter Friedrichsen
Further Information

Publication History

Publication Date:
25 July 2012 (online)

Zusammenfassung

Die Zahl der an Herzinsuffizienz Erkrankten steigt in den Industrienationen stetig an. Die Optimierung des Energiestoffwechsels der Kardiomyozyten scheint ein neuer, vielversprechender Ansatz zur Prävention und Therapie der Herzinsuffizienz zu sein. Eine kontinuierliche und v. a. ungestörte ATP-Synthese zur Deckung des Energiebedarfes ist wesentlich für die kardiale Funktion. Einige Mikronährstoffe, die für die ATP-Synthese eine wichtige Rolle spielen, sind näher spezifiziert, Dosierungsbeispiele angeführt.

Abstract

The number of people suffering from cardiac insufficiency is constantly increasing in the industrialized nations. The optimization of the energy metabolism of the cardiomyocytes seems to be a new, very promising approach for the prevention and therapy of cardiac insufficiency. A continuous and especially undisturbed ATP synthesis to cover the energy requirement is essential for the cardiac function. Some micronutrients, which play an important role in the ATP synthesis, are specified, examples for dosages are given.

 
  • Literatur

  • 1 Allard ML, Jeejeebhoy KN, Sole MJ. The management of conditioned nutritional requirements in heart failure. Heart Fail Rev 2006; 11 (1): 75-82
  • 2 Aquilani R, Viglio S, Iadarola P et al. Oral amino acid supplements improve exercise capacities in elderly patients with chronic heart failure. Am J Cardiol 2008; 101: 104E-10E
  • 3 Gustafsson AB, Gottlieb RA. Heart mitochondria: gates of life and death. Cardiovasc Res 2007; 77: 334-343
  • 4 Ingwall JS, Weiss RG. Is the failing heart energy starved?. Circ Res 2004; 95: 135-145
  • 5 Murray AJ, Edwards LM, Clarke K. Mitochondria and heart failure. Curr Opin Clin Nutr Metab Care 2007; 10: 704-711
  • 6 Sheeran FL, Pepe S. Energy deficiency in the failing heart: linking increased reactive oxygen species and disruption of oxidative phosphorylation rate. Biochem Biophys Acta 2006; 1757: 543-552
  • 7 Sica DA. Loop diuretic therapy, thiamine balance, and heart failure. Congest Heart Fail 2007; 13: 244-7
  • 8 Smithline HA. Thiamine for the treatment of acute decompensated heart failure. Am J Emerg Med 2007; 25: 124-6
  • 9 Sole MJ, Jeejeebhoy KN. Conditioned nutritional requirements and the pathogenesis and treatment of myocardial failure. Curr Opin Clin Nutr Metab Care 2000; 3: 417-24 Heart Fail Rev 2006; 11 75–82
  • 10 Azuma J. Usefulness of taurine in chronic congestive heart failure and its prospec- tive application. Jpn Circ J 1992; 56 (1): 95-99
  • 11 Beyranvand MR. Effect of taurine supplementation on exercise capacity of patients with heart failure. J Cardiol 2011; 57 (3): 333-337
  • 12 Shimon I. Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy. Am J Med 1995; 98 (5): 485-490
  • 13 Tsutsui H. Mitochondrial oxidative stress and heart failure. Intern Med 2006; 45: 809-813
  • 14 Weber KT et al. Macro- and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium. Cardiovasc Res 2009; 81: 500-8
  • 15 Witte KK et al. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur Heart J 2005; 26: 2238-44
  • 16 Zhang M, Shah AM. Role of reactive oxygen species in myocardial remodeling. Curr Heart Fail Rep 2007; 4: 26-30
  • 17 Zittermann A et al. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?. J Am Coll Cardiol 2003; 41: 105-12