Horm Metab Res 2010; 42(5): 358-363
DOI: 10.1055/s-0030-1248263
Humans, Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Effects of Combined Oral Contraceptive Ethinylestradiol (30 μg) and Dienogest (2 mg) on Carbohydrate Metabolism During 1 Year of Conventional or Extended-Cycle Use

I. Wiegratz1 , S. Stahlberg1 , T. Manthey1 , N. Sänger1 , K. Mittmann2 , E. Palombo-Kinne2 , U. Mellinger2 , E. Lange2 , H. Kuhl1
  • 1Center of Obstetrics and Gynecology, University Hospital of Frankfurt, Frankfurt/M, Germany
  • 2Jenapharm GmbH & Co KG, Jena, Germany
Further Information

Publication History

received 02.07.2009

accepted 20.01.2010

Publication Date:
08 March 2010 (online)

Abstract

The effects of extended regimens of combined oral contraceptives (COCs) on carbohydrate metabolism are largely unknown. The present study compared the effects of a COC containing 30 μg ethinylestradiol and 2 mg dienogest (EE/DNG) in conventional and extended-cycle regimen over 1 year. Parameters of carbohydrate metabolism were measured in 59 women treated with EE/DNG either conventionally (13 cycles of 21+7 days) or in extended-cycle regimen (4 cycles of 84+7 days). Blood samples were taken in a control cycle, and at 3 and 12 months of treatment. The mean levels of HbA1c and fasting glucose levels remained stable in both conventional and extended-regimen of EE/DNG. The mean levels of fasting insulin and C-peptide underwent comparable increases in both regimens, suggesting a similar readjustment of glucose metabolism via slightly increased insulin secretion. For both regimens, the response to the oral glucose tolerance test (OGTT) showed a slightly impaired glucose tolerance and insulin resistance at 3 months. These changes improved or returned to baseline at 12 months. Accordingly, the mean index for insulin resistance (homeostasis model assessment of insulin resistance, HOMA-IR) increased and the mean insulin sensitivity index [ISI (composite)] decreased modestly in both groups. The present study demonstrates that there are no statistically significant differences between the effects of conventional and extended-cycle treatment on carbohydrate metabolism over 1 year of treatment. In general, the effects of both regimens were moderate and mostly transient.

References

Correspondence

PD Dr. I. Wiegratz

Department of Obstetrics and Gynecology

J. W. Goethe University

Theodor-Stern-Kai 7

60590 Frankfurt am Main

Germany

Phone: +49/69/6301 5708

Fax: + 49/69/6301 5522

Email: [email protected]