Semin Liver Dis 2010; 30(1): 107-112
DOI: 10.1055/s-0030-1247137

© Thieme Medical Publishers

Hepatocellular Carcinoma and Hepatic Adenocarcinosarcoma in a Patient with Hepatitis B Virus-Related Cirrhosis

Qian Zhao1 , Chang-Qing Su2 , Hui Dong1 , Xin-Yuan Lu1 , Meng-Chao Wu3 , Wen-Ming Cong1
  • 1Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
  • 2Laboratory of Gene and Viral Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
  • 3 Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
Further Information

Publication History

Publication Date:
19 February 2010 (online)


The authors present the case of a 48-year-old man with hepatitis B cirrhosis, who developed two primary malignant liver tumors that were morphologically distinct from each other. The first tumor was a hepatocellular carcinoma and the second tumor, detected 17 months later was a hepatic carcinosarcoma with cholangiocarcinomatous and sarcomatous components, without any hepatocellular carcinoma component. Clonality studies using microsatellite-based loss of heterozygosity (LOH) demonstrated different LOH patterns existed between the hepatocellular carcinoma and the hepatic carcinosarcoma, indicative of different clonal origins. The authors discuss the histogenesis, histopathologic diagnosis, and clinical behavior of hepatic carcinosarcoma.


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Wen-Ming CongM.D. 

Department of Pathology, Eastern Hepatobiliary Surgery Hospital

Second Military Medical University, Changhai Road, Shanghai 200438, China