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Horm Metab Res 2010; 42(6): 435-439
DOI: 10.1055/s-0029-1246189
Original Article

© Georg Thieme Verlag KG Stuttgart · New York

Is Primary Aldosteronism Associated with Diabetes Mellitus? Results of the German Conn's Registry

M. Reincke1 , C. Meisinger2 , R. Holle3 , M. Quinkler4 , S. Hahner5 , F. Beuschlein1 , M. Bidlingmaier1 , J. Seissler1 , S. Endres1 for the Participants of the German Conn's Registry
  • 1Medizinische Klinik Innenstadt, Ludwig-Maximilians-Universität München, München, Germany
  • 2Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
  • 3Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, Neuherberg, Germany
  • 4Klinische Endokrinologie, Charité Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany
  • 5Medizinische Klinik und Poliklinik I, Julius-Maximilians-Universität, Würzburg, Germany
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Publication History

received 22.10.2009

accepted 15.12.2009

Publication Date:
29 January 2010 (online)

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Abstract

Aldosterone excess in the context of primary aldosteronism (PA) has been associated with impaired glucose tolerance and diabetes mellitus. We retrospectively assessed the prevalence of diabetes mellitus in patients from the German Conn's Register and compared the data with those from hypertensive subjects of a population-based survey. In a case-control study, we have compared 638 patients with PA from the German Conn's registry who were treated in 6 German centers with 897 hypertensive control subjects from the population-based F3 survey of the Cooperative Health Research in the Region of Augsburg (KORA). The samples were matched for age, sex, and blood pressure in a 1:1 ratio. Risk factors associated with the presence of diabetes mellitus were calculated in 638 patients with PA and 897 hypertensive controls. In the case control study, the diabetes prevalence was calculated in 338 cases and controls. In patients with primary aldosteronism, age, BMI, and a higher number of antihypertensive drugs (lowest tertile vs. highest tertile) were variables associated with diabetes mellitus. In contrast, serum potassium and plasma aldosterone concentrations were not associated with higher diabetes prevalence, whereas diastolic blood pressure was inversely associated with diabetes mellitus. Diabetes mellitus was more prevalent in patients with PA than in 338 matched controls (23 vs. 10% in controls). Our data for the German population show that diabetes mellitus is more prevalent in patients with primary aldosteronism than in hypertensive controls.

Key words

aldosterone - adrenal - mineralocorticoid

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Correspondence

Prof. Dr. M. Reincke

Medizinische Klinik – Innenstadt Klinikum der Universität München

Ziemssenstraße 1

80336 München

Germany

Phone: +49 89 5160 2100

Fax: +49 89 5160 4428

Email: martin.reincke@med.uni-muenchen.de