RSS-Feed abonnieren
DOI: 10.1055/s-0029-1245501
© Georg Thieme Verlag KG Stuttgart · New York
Endovaskuläre Therapieoptionen bei femoropoplitealer pAVK
Endovascular Therapy Options in Femoro-Popliteal PADPublikationsverlauf
eingereicht: 12.2.2010
angenommen: 13.5.2010
Publikationsdatum:
05. Juli 2010 (online)

Zusammenfassung
Die femoropopliteale pAVK stellt weiterhin eine Herausforderung in der endovaskulären Behandlung dar. Die Zahl an endovaskulären femoropoplitealen Eingriffen nimmt stetig zu. Trotz neuer technischer Entwicklungen steht eine dauerhafte Behandlung noch immer aus. Die Entwicklung der minimalisierten Systeme schreitet weiter voran. Hierzu zählen insbesondere diejenigen Verfahren, die eine mechanische Behandlung mit einer Medikamentenapplikation kombinieren. Des Weiteren zeigen sich alte und neue Trends, wie die Atherektomie, die weiter verbessert werden und eine Behandlungsoption darstellen. Dieser Übersichtsartikel soll zunächst die Indikationen zur endovaskulären Behandlung darstellen und im weiteren die zur Zeit etablierten und modernen Behandlungstechniken beleuchten.
Abstract
The endovascular treatment of femoro-popliteal PAD is still challenging. The number of endovascular procedures in this vessel segment has increased over the past years. Despite new technologies, the outcome of endovascular therapy in terms of durability is still weak. In the meantime, the latest developments are progressing, such as the combination of mechanical angioplasty and drug delivery. Additionally, there are former techniques, such as debulking by atherectomy, which have been technically improved and now contribute to modern concepts of endovascular treatment. This article provides an overview on treatment indications and technical options including the latest technical developments.
Key words
vascular - angioplasty - interventional procedures
Literatur
- 1
McDaniel M D, Cronenwett J L.
Basic data related to the natural history of intermittent claudication.
Ann Vasc Surg.
1989;
3
273-277
Reference Ris Wihthout Link
- 2
Weitz J I, Byrne J, Clagett G P et al.
Diagnosis and treatment of chronic arterial insufficiency of the lower extremities:
a critical review.
Circulation.
1996;
94
3026-3049
Reference Ris Wihthout Link
- 3
Dormandy J, Mahir M, Ascady G et al.
Fate of the patient with chronic leg ischaemia. A review article.
J Cardiovasc Surg (Torino).
1989;
30
50-57
Reference Ris Wihthout Link
- 4
Norgren L, Hiatt W R, Dormandy J A et al.
Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II).
Eur J Vasc Endovasc Surg.
2007;
33
S1-S75
Reference Ris Wihthout Link
- 5
Hirsch A T, Haskal Z J, Hertzer N R et al.
ACC/AHA Guidelines for the Management of Patients with Peripheral Arterial Disease
(lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report
from the American Associations for Vascular Surgery/Society for Vascular Surgery,
Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine
and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice
Guidelines (writing committee to develop guidelines for the management of patients
with peripheral arterial disease) – summary of recommendations.
J Vasc Interv Radiol.
2006;
17
1383-1397
; quiz 1398
Reference Ris Wihthout Link
- 6
Hirsch A T, Haskal Z J, Hertzer N R et al.
ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial
disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative
report from the American Association for Vascular Surgery/Society for Vascular Surgery,
Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine
and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice
Guidelines (Writing Committee to Develop Guidelines for the Management of Patients
With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular
and Pulmonary Rehabilitation, National Heart, Lung, and Blood Institute, Society for
Vascular Nursing, TransAtlantic Inter-Society Consensus and Vascular Disease Foundation.
Circulation.
2006;
113
e463-e654
Reference Ris Wihthout Link
- 7
Jonker F HW, Schloesser F JV, Moll F L et al.
Dynamic forces in the SFA and popliteal artery during knee flexion. Consequences of
stress to consider for stent durability and design.
Endovascular Today.
2008;
5
53-58
Reference Ris Wihthout Link
- 8
Zeller T.
Current state of endovascular treatment of femoro-popliteal artery disease.
Vasc Med.
2007;
12
223-234
Reference Ris Wihthout Link
- 9
Noory E, Rastan A, Schwarzwalder U et al.
Retrograde transpopliteal recanalization of chronic superficial femoral artery occlusion
after failed re-entry during antegrade subintimal angioplasty.
J Endovasc Ther.
2009;
16
619-623
Reference Ris Wihthout Link
- 10
Wiesinger B, Steinkamp H, Konig C et al.
Technical report and preliminary clinical data of a novel catheter for luminal re-entry
after subintimal dissection.
Invest Radiol.
2005;
40
725-728
Reference Ris Wihthout Link
- 11
Dotter C T, Judkins M P.
Transluminal Treatment of Arteriosclerotic Obstruction. Description of a New Technic
and a Preliminary Report of Its Application.
Circulation.
1964;
30
654-670
Reference Ris Wihthout Link
- 12
Bown M J, Bolia A, Sutton A J.
Subintimal angioplasty: meta-analytical evidence of clinical utility.
Eur J Vasc Endovasc Surg.
2009;
38
323-337
Reference Ris Wihthout Link
- 13
Charalambous N, Schafer P J, Trentmann J et al.
Percutaneous Intraluminal Recanalization of Long, Chronic Superficial Femoral and
Popliteal Occlusions Using the Frontrunner XP CTO Device: A Single-Center Experience.
Cardiovasc Intervent Radiol.
2010;
33
25-33
Reference Ris Wihthout Link
- 14
Al-Ameri H, Shin V, Mayeda G S et al.
Peripheral chronic total occlusions treated with subintimal angioplasty and a true
lumen re-entry device.
J Invasive Cardiol.
2009;
21
468-472
Reference Ris Wihthout Link
- 15
Al-Ameri H, Mayeda G S, Shavelle D M.
Use of high-frequency vibrational energy in the treatment of peripheral chronic total
occlusions.
Catheter Cardiovasc Interv.
2009;
74
1110-1115
Reference Ris Wihthout Link
- 16
Husmann M, Federer J, Keo H H et al.
Bailout revascularization of chronic femoral artery occlusions with the new outback
catheter following failed conventional endovascular intervention.
J Endovasc Ther.
2009;
16
206-212
Reference Ris Wihthout Link
- 17
Kickuth R, Ludwig K C, Do D D et al.
Steuerung der Interventionen bei subintimaler Rekanalisation und Fenestration von
Dissektionsmembranen durch einen neuartigen zweilumigen intravaskulären Ultraschallkatheter.
Fortschr Röntgenstr.
2006;
178
898-905
Reference Ris Wihthout Link
- 18
Scheinert D, Braunlich S, Scheinert S et al.
Initial clinical experience with an IVUS-guided transmembrane puncture device to facilitate
recanalization of total femoral artery occlusions.
EuroIntervention.
2005;
1
115-119
Reference Ris Wihthout Link
- 19
Clark T W, Groffsky J L, Soulen M C.
Predictors of long-term patency after femoropopliteal angioplasty: results from the
STAR registry.
J Vasc Interv Radiol.
2001;
12
923-933
Reference Ris Wihthout Link
- 20
Sabeti S, Schillinger M, Amighi J et al.
Primary patency of femoropopliteal arteries treated with nitinol versus stainless
steel self-expanding stents: propensity score-adjusted analysis.
Radiology.
2004;
232
516-521
Reference Ris Wihthout Link
- 21
Scheinert D, Scheinert S, Sax J et al.
Prevalence and clinical impact of stent fractures after femoropopliteal stenting.
J Am Coll Cardiol.
2005;
45
312-315
Reference Ris Wihthout Link
- 22
Zeller T, Tiefenbacher C, Steinkamp H J et al.
Nitinol stent implantation in TASC A and B superficial femoral artery lesions: the
Femoral Artery Conformexx Trial (FACT).
J Endovasc Ther.
2008;
15
390-398
Reference Ris Wihthout Link
- 23
Krankenberg H, Schluter M, Steinkamp H J et al.
Nitinol stent implantation versus percutaneous transluminal angioplasty in superficial
femoral artery lesions up to 10 cm in length: the femoral artery stenting trial (FAST).
Circulation.
2007;
116
285-292
Reference Ris Wihthout Link
- 24
Dick P, Wallner H, Sabeti S et al.
Balloon angioplasty versus stenting with nitinol stents in intermediate length superficial
femoral artery lesions.
Catheter Cardiovasc Interv.
2009;
74
1090-1095
Reference Ris Wihthout Link
- 25
Schillinger M, Sabeti S, Loewe C et al.
Balloon angioplasty versus implantation of nitinol stents in the superficial femoral
artery.
N Engl J Med.
2006;
354
1879-1888
Reference Ris Wihthout Link
- 26
Bischoff B.
RESILIENT II-1-Jahres-Ergebnisse. Randomisierte Studie zum Vergleich alleiniger PTA
versus PTA plus LifeStent bei Stenosen der A. femoralis superficialis und der proximalen
A. poplitea.
Herz.
2008;
33
313
Reference Ris Wihthout Link
- 27
Bosiers M, Torsello G, Gissler H M et al.
Nitinol stent implantation in long superficial femoral artery lesions: 12-month results
of the DURABILITY I study.
J Endovasc Ther.
2009;
16
261-269
Reference Ris Wihthout Link
- 28
Berceli S A.
Revision of vein bypass grafts: factors affecting durability of interventions.
Semin Vasc Surg.
2009;
22
261-266
Reference Ris Wihthout Link
- 29
Cotroneo A R, Iezzi R.
The Role of ”Cutting” Balloon Angioplasty for the Treatment of Short Femoral Bifurcation
Steno-Obstructive Disease.
Cardiovasc Intervent Radiol.
2010;
epub ahead of print, PMID: 20098989
Reference Ris Wihthout Link
- 30
Speck U, Scheller B, Abramjuk C et al.
Neointima inhibition: comparison of effectiveness of non-stent-based local drug delivery
and a drug-eluting stent in porcine coronary arteries.
Radiology.
2006;
240
411-418
Reference Ris Wihthout Link
- 31
Scheller B, Hehrlein C, Bocksch W et al.
Treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter.
N Engl J Med.
2006;
355
2113-2124
Reference Ris Wihthout Link
- 32
Tepe G, Zeller T, Albrecht T et al.
Local delivery of paclitaxel to inhibit restenosis during angioplasty of the leg.
N Engl J Med.
2008;
358
689-699
Reference Ris Wihthout Link
- 33
Duda S H, Bosiers M, Lammer J et al.
Sirolimus-eluting versus bare nitinol stent for obstructive superficial femoral artery
disease: the SIROCCO II trial.
J Vasc Interv Radiol.
2005;
16
331-338
Reference Ris Wihthout Link
- 34
Duda S H, Bosiers M, Lammer J et al.
Drug-eluting and bare nitinol stents for the treatment of atherosclerotic lesions
in the superficial femoral artery: long-term results from the SIROCCO trial.
J Endovasc Ther.
2006;
13
701-710
Reference Ris Wihthout Link
- 35
Bosiers M, Deloose K, Keirse K et al.
Are drug-eluting stents the future of SFA treatment?.
J Cardiovasc Surg.
2010;
51
115-119
Reference Ris Wihthout Link
- 36
Ahmadi R, Schillinger M, Maca T et al.
Femoropopliteal arteries: immediate and long-term results with a Dacron-covered stent-graft.
Radiology.
2002;
223
345-350
Reference Ris Wihthout Link
- 37
Saxon R R, Dake M D, Volgelzang R L et al.
Randomized, multicenter study comparing expanded polytetrafluoroethylene-covered endoprosthesis
placement with percutaneous transluminal angioplasty in the treatment of superficial
femoral artery occlusive disease.
J Vasc Interv Radiol.
2008;
19
823-832
Reference Ris Wihthout Link
- 38
Jahnke T, Andresen R, Muller-Hulsbeck S et al.
Hemobahn stent-grafts for treatment of femoropopliteal arterial obstructions: midterm
results of a prospective trial.
J Vasc Interv Radiol.
2003;
14
41-51
Reference Ris Wihthout Link
- 39
Saxon R R, Coffman J M, Gooding J M et al.
Long-term patency and clinical outcome of the Viabahn stent-graft for femoropopliteal
artery obstructions.
J Vasc Interv Radiol.
2007;
18
1341-1349
; quiz 1350
Reference Ris Wihthout Link
- 40
Waksman R, Laird J R, Jurkovitz C T et al.
Intravascular radiation therapy after balloon angioplasty of narrowed femoropopliteal
arteries to prevent restenosis: results of the PARIS feasibility clinical trial.
J Vasc Interv Radiol.
2001;
12
915-921
Reference Ris Wihthout Link
- 41
Gallino A, Do D D, Alerci M et al.
Effects of probucol versus aspirin and versus brachytherapy on restenosis after femoropopliteal
angioplasty: the PAB randomized multicenter trial.
J Endovasc Ther.
2004;
11
595-604
Reference Ris Wihthout Link
- 42
Wolfram R M, Budinsky A C, Pokrajac B et al.
Vascular brachytherapy with 192Ir after femoropopliteal stent implantation in high-risk
patients: twelve-month follow-up results from the Vienna-5 trial.
Radiology.
2005;
236
343-351
Reference Ris Wihthout Link
- 43
Wolfram R M, Budinsky A C, Pokrajac B et al.
Endovascular brachytherapy for prophylaxis of restenosis after femoropopliteal angioplasty:
five-year follow-up--prospective randomized study.
Radiology.
2006;
240
878-884
Reference Ris Wihthout Link
- 44
Kehlbach R, Dittmann H, Schmid T et al.
Early effects of rhenium-188 treatment on proliferation, migration, and matrix synthesis
of cultured human aortic smooth muscle cells.
Strahlenther Onkol.
2006;
182
164-171
Reference Ris Wihthout Link
- 45
Henning E, Dittmann H, Wiskirchen J et al.
Dosisabhängige Auswirkungen des kombinierten beta-gamma-Emitters 188Rhenium auf humane
Endothelzellen und humane vaskuläre glatte Muskelzellen.
Fortschr Röntgenstr.
2004;
176
404-408
Reference Ris Wihthout Link
- 46
Ahn S S.
Infrainguinal atherectomy using the Auth Rotablator.
J Endovasc Surg.
1995;
2
317-319
Reference Ris Wihthout Link
- 47
Tielbeek A V, Vroegindeweij D, Buth J et al.
Comparison of balloon angioplasty and Simpson atherectomy for lesions in the femoropopliteal
artery: angiographic and clinical results of a prospective randomized trial.
J Vasc Interv Radiol.
1996;
7
837-844
Reference Ris Wihthout Link
- 48
Vroegindeweij D, Tielbeek A V, Buth J et al.
Directional atherectomy versus balloon angioplasty in segmental femoropopliteal artery
disease: two-year follow-up with color-flow duplex scanning.
J Vasc Surg.
1995;
21
255-268
; discussion 268 – 259
Reference Ris Wihthout Link
- 49
Ramaiah V, Gammon R, Kiesz S et al.
Midterm outcomes from the TALON Registry: treating peripherals with SilverHawk: outcomes
collection.
J Endovasc Ther.
2006;
13
592-602
Reference Ris Wihthout Link
- 50
Zeller T, Rastan A, Sixt S et al.
Long-term results after directional atherectomy of femoro-popliteal lesions.
J Am Coll Cardiol.
2006;
48
1573-1578
Reference Ris Wihthout Link
- 51
Schwarzwälder U, Zeller T.
Debulking Procedures: Potential Device Specific Indications.
Tech Vasc Interv Radiol.
2010;
13
43-53
Reference Ris Wihthout Link
- 52
Wissgott C, Kamusella P, Richter A et al.
Behandlung von Lasionen der femoropoplitealen Arterien mittels eines neuartigen Rotationsatherektomiesystems:
Erste single-center Erfahrungen mit dem Pathway PVTM Atherectomy System.
Fortschr Röntgenstr.
2008;
180
809-815
Reference Ris Wihthout Link
- 53
Zeller T, Krankenberg H, Rastan A et al.
Percutaneous rotational and aspiration atherectomy in infrainguinal peripheral arterial
occlusive disease: a multicenter pilot study.
J Endovasc Ther.
2007;
14
357-364
Reference Ris Wihthout Link
- 54
Zeller T, Krankenberg H, Steinkamp H et al.
One-year outcome of percutaneous rotational atherectomy with aspiration in infrainguinal
peripheral arterial occlusive disease: the multicenter pathway PVD trial.
J Endovasc Ther.
2009;
16
653-662
Reference Ris Wihthout Link
- 55
Laird J R, Reiser Jr C, Biamino G et al.
Excimer laser assisted angioplasty for the treatment of critical limb ischemia.
J Cardiovasc Surg.
2004;
45
239-248
Reference Ris Wihthout Link
- 56
Das T S.
Excimer laser-assisted angioplasty for infrainguinal artery disease.
J Endovasc Ther.
2009;
16
II98-104
Reference Ris Wihthout Link
- 57
Scheinert D, Laird J R, Schroder Jr M et al.
Excimer laser-assisted recanalization of long, chronic superficial femoral artery
occlusions.
J Endovasc Ther.
2001;
8
156-166
Reference Ris Wihthout Link
- 58
Laird J R, Zeller T, Gray B H et al.
Limb salvage following laser-assisted angioplasty for critical limb ischemia: results
of the LACI multicenter trial.
J Endovasc Ther.
2006;
13
1-11
Reference Ris Wihthout Link
Klaus Brechtel
Dept. für diagnostische und interventionelle Radiologie, Universitätsklinik Tübingen
Hoppe-Seyler-Str. 3
72076 Tübingen
Telefon: ++ 49/70 71/2 98 20 87
Fax: ++ 49/70 71/29 59 41
eMail: klaus.brechtel@med.uni-tuebingen.de