Dialyse aktuell 2009; 13(10): 572-575
DOI: 10.1055/s-0029-1245022
Forum der Industrie

© Georg Thieme Verlag KG Stuttgart ˙ New York

Chronische Nierenerkrankung - Möglichkeiten der kardiorenalen Protektion

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Publikationsverlauf

Publikationsdatum:
05. Januar 2010 (online)

Auch verfügbar aufeRef
 

Die Mehrzahl der Dialysepatienten verstirbt aufgrund kardiovaskulärer Ursachen [1]. Wie Prof. Eberhard Ritz, Heidelberg, auf dem Kongress für Nephrologie 2009 in Göttingen ausführte, erhöht eine geringe GFR-Reduktion (GFR: glomeruläre Filtrationsrate) - auch innerhalb des GFR-Normbereichs - bereits bei gesunden Menschen das relative Risiko für einen kardiovaskulären Tod sowie die Inzidenz koronarer Schädigungen [2], [3]. Das relative Risiko steigt um jeweils 1,26 pro 5 ml/min GFR-Verlust [4]. Hinter einer normalen GFR kann sich also eine deutliche Nierenfunktionsstörung verbergen, da die verbliebenen Nephrone mittels kompensatorischer Hyperfiltration eine lange Zeit die Funktionseinschränkung des Organs ausgleichen können.

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