Neuropediatrics 2009; 40(4): 174-178
DOI: 10.1055/s-0029-1243172
Original Article

© Georg Thieme Verlag KG Stuttgart · New York

Macrophagic Myofasciitis Plus (Distinct Types of Muscular Dystrophy)

H. D. Müller1 , F. K. H. van. Landeghem2 , 4 , P. F. Schmidt3 , C. Sommer1 , H. H. Goebel1 , 2
  • 1Department of Neuropathology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
  • 2Institute of Neuropathology, Charité Universitätsmedizin, Berlin, Germany
  • 3Institute of Legal Medicine, Westphalian Wilhelms University, Münster, Germany
  • 4Present address: Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Further Information

Publication History

received 23.06.2009

accepted 19.10.2009

Publication Date:
04 February 2010 (online)

Abstract

Macrophagic myofasciitis (MMF) is a well-known lesion following vaccination with aluminium-containing vaccines. It has abundantly been reported in adults and several times in children, often in single patients or in rather small cohorts. Only few of these published reports on children have shown distinct myopathology of another neuromuscular disease except for MMF. Indications for biopsy often were nondescript clinical features in children, such as hypotonia or delay in motor development but, apparently, never that of suspected MMF. Thus, in previous reports as well as in our two patients, encountering MMF in the biopsied tissue specimens was coincidental. Our two unrelated patients with MMF also had two separate types of muscular dystrophy, a merosinopathy and dystrophinopathy, showing a combination of myopathologically well-defined neuromuscular diseases, muscular dystrophies and MMF. Detecting such a combination of two separate conditions may, in the future, be rare when non-invasive techniques, e. g., genetic, will have replaced muscle biopsy in ascertaining hereditary neuromuscular conditions, especially in children.

References

Correspondence

Dr. Harald D. Müller, MD 

Department of Neuropathology

University Medical Center of the Johannes Gutenberg University

Mainz

Langenbeckstr. 1

55131 Mainz

Germany

Phone: +49/6131/174 332

Fax: +49/6131/176 606

Email: mueller@neuropatho.klinik.uni-mainz.de