Antiplasmodial Activity of the Alkaloids of Peschiera fuchsiaefolia

Abstract

The tertiary and quaternary alkaloids isolated from the stem bark, root bark and seeds of Peschiera fuchsiaefolia are reported. The tertiary alkaloid crude extract from the stem bark was tested in vitro against Plasmodium falciparum on the basis of the antimalarial use of the plant. It showed good activity against both the D₆ strain (IC₅₀ = 495ng/ml) and chloroquine-resistant W₂ strain (IC₅₀ = 817ng/ml) and voacamine was the most active of the tested alkaloids (IC₅₀ = 238ng/ml for D₆ and 290ng/ml for W₂). The tertiary alkaloid crude extract from the root bark of the same plant is more active than voacamine (IC₅₀ = 179ng/ml for D₆ and 282ng/ml for W₂ strain), and is particularly rich in dimeric alkaloids (0.22 % of the vegetable material).

References

• 1 Braga R M, Leitão Filho H F, Reis F De A M. Phytochemistry 1984 23: 175-178
• 2 Braga R M, Reis F De A M. Phytochemistry 1987 26: 833-836
• 3 Rossi S. Torino personal communication 1996
• 4 Min Y ou, Xianjian M a, Mukherjee R, Farnsworth N R, Cordell G A, Kinghorn A D, Pezzuto J M. J Nat Prod 1994 57: 1517-1522
• 5 Cordell G A, Angerhofer C K, Pezzuto J M. Pure & Appl Chem 1994 66: 2283-2286
• 6 Desjardins R E, Canfield C J, Haynes J D, Chulay J D. Antimicrob. Agents Chemother 1979 16: 710-718
• 7 Gunasekera S, Cordell G A, Farnsworth N R. Phytochemistry 1980 19: 1213-1218
• 8 Ahond A, Bui A -M, Potier P, Hagaman E W, Wenkert E. J Org Chem 1976 41: 1878-1879
• 9 Clivio P, Richard B, Deverre J -R, Sevenet T, Zeches M, Le Men-Olivier L. Phytochemistry 1991 30: 3785-3792
• 10 Jokela R, Lounasmaa M. Heterocycles 1996 43: 1015-1020
• 11 Damak M, Poupat C, Ahond A. Tetrahedron Lett 1976 39: 3531-3534
• 12 Lemos T LG, Andrade C HS, Guimarães A M, Wolter Filho W, Braz Filho R. J Braz Chem Soc 1996 7: 123-126
• 13 Urrea M, Ahond A, Bui A M, Potier P. Bull Soc Chim Fr II 1981: 147-149
• 14 Le Men-Olivier L, Le Men J, Massiot G, Richard B, Mulamba T, Potier P, Husson H -P, Beek T van, Verpoorte R. Bull Soc Chim Fr II 1985: 94-97
• 15 Xiao-Zhang F eng, Kan C, Husson H -P, Potier P, Siew-Kwong K an, Lounasmaa M. J Nat Prod 1981 44: 670-675