Download PDF
Planta Med 2000; 66(1): 93-95
DOI: 10.1055/s-0029-1243122
Letter

© Georg Thieme Verlag Stuttgart · New York

Antiplasmodial Activity of the Alkaloids of Peschiera fuchsiaefolia

Elena Federici1 , Giovanna Palazzino1 , Marcello Nicoletti2 , Corrado Galeffi1 ,*
  • 1Istituto Superiore di Sanità, Roma, Italy
  • 2Dipartimento di Biologia Vegetale, Università ”La Sapienza”, Roma, Italy
Further Information

Publication History

Received: March 18, 1999

Accepted: May 22, 1999

Publication Date:
24 November 2009 (online)

    Permissions and Reprints

Abstract

The tertiary and quaternary alkaloids isolated from the stem bark, root bark and seeds of Peschiera fuchsiaefolia are reported. The tertiary alkaloid crude extract from the stem bark was tested in vitro against Plasmodium falciparum on the basis of the antimalarial use of the plant. It showed good activity against both the D6 strain (IC50 = 495ng/ml) and chloroquine-resistant W2 strain (IC50 = 817ng/ml) and voacamine was the most active of the tested alkaloids (IC50 = 238ng/ml for D6 and 290ng/ml for W2). The tertiary alkaloid crude extract from the root bark of the same plant is more active than voacamine (IC50 = 179ng/ml for D6 and 282ng/ml for W2 strain), and is particularly rich in dimeric alkaloids (0.22 % of the vegetable material).

References

  • 1 Braga R M, Leitão Filho H F, Reis F De A M. Phytochemistry 1984 23: 175-178
    PubMed
  • 2 Braga R M, Reis F De A M. Phytochemistry 1987 26: 833-836
    PubMed
  • 3 Rossi S. Torino personal communication 1996
    PubMed
  • 4 Min Y ou, Xianjian M a, Mukherjee R, Farnsworth N R, Cordell G A, Kinghorn A D, Pezzuto J M. J Nat Prod 1994 57: 1517-1522
    PubMed
  • 5 Cordell G A, Angerhofer C K, Pezzuto J M. Pure & Appl Chem 1994 66: 2283-2286
    PubMed
  • 6 Desjardins R E, Canfield C J, Haynes J D, Chulay J D. Antimicrob. Agents Chemother 1979 16: 710-718
    PubMed
  • 7 Gunasekera S, Cordell G A, Farnsworth N R. Phytochemistry 1980 19: 1213-1218
    PubMed
  • 8 Ahond A, Bui A -M, Potier P, Hagaman E W, Wenkert E. J Org Chem 1976 41: 1878-1879
    PubMed
  • 9 Clivio P, Richard B, Deverre J -R, Sevenet T, Zeches M, Le Men-Olivier L. Phytochemistry 1991 30: 3785-3792
    PubMed
  • 10 Jokela R, Lounasmaa M. Heterocycles 1996 43: 1015-1020
    PubMed
  • 11 Damak M, Poupat C, Ahond A. Tetrahedron Lett 1976 39: 3531-3534
    PubMed
  • 12 Lemos T LG, Andrade C HS, Guimarães A M, Wolter Filho W, Braz Filho R. J Braz Chem Soc 1996 7: 123-126
    PubMed
  • 13 Urrea M, Ahond A, Bui A M, Potier P. Bull Soc Chim Fr II 1981: 147-149
    PubMed
  • 14 Le Men-Olivier L, Le Men J, Massiot G, Richard B, Mulamba T, Potier P, Husson H -P, Beek T van, Verpoorte R. Bull Soc Chim Fr II 1985: 94-97
    PubMed
  • 15 Xiao-Zhang F eng, Kan C, Husson H -P, Potier P, Siew-Kwong K an, Lounasmaa M. J Nat Prod 1981 44: 670-675
    PubMed

Prof. Dr. C. Galeffi

Istituto Superiore di Sanità

V. le Regina Elena 299

I-00161 Rome

Italy

Email: galeffi@iss.it

Fax: +396 49387100

      >