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DOI: 10.1055/s-0029-1243122
© Georg Thieme Verlag Stuttgart · New York
Antiplasmodial Activity of the Alkaloids of Peschiera fuchsiaefolia
Publication History
Received: March 18, 1999
Accepted: May 22, 1999
Publication Date:
24 November 2009 (online)
Abstract
The tertiary and quaternary alkaloids isolated from the stem bark, root bark and seeds of Peschiera fuchsiaefolia are reported. The tertiary alkaloid crude extract from the stem bark was tested in vitro against Plasmodium falciparum on the basis of the antimalarial use of the plant. It showed good activity against both the D6 strain (IC50 = 495ng/ml) and chloroquine-resistant W2 strain (IC50 = 817ng/ml) and voacamine was the most active of the tested alkaloids (IC50 = 238ng/ml for D6 and 290ng/ml for W2). The tertiary alkaloid crude extract from the root bark of the same plant is more active than voacamine (IC50 = 179ng/ml for D6 and 282ng/ml for W2 strain), and is particularly rich in dimeric alkaloids (0.22 % of the vegetable material).
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Prof. Dr. C. Galeffi
Istituto Superiore di Sanità
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Italy
Email: galeffi@iss.it
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