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DOI: 10.1055/s-0029-1243121
© Georg Thieme Verlag Stuttgart · New York
Interaction of Flavones from the Roots of Scutellaria baicalensis with the Benzodiazepine Site
Publication History
Received: April 21, 1999
Accepted: June 27, 1999
Publication Date:
24 November 2009 (online)
Abstract
A radioreceptor binding assay was used to guide the isolation of four chemical constituents in the organic solvent extracts of Scutellaria baicalensis Georgi capable of binding to the benzodiazepine site (BZD-S) of the GABAA receptor: wogonin (Ki = 2.03 ± 0.24µM), baicalin (Ki = 77.10 ± 4.79µM), baicalein (Ki = 5.69 ± 0.95µM), and scutellarein (Ki = 12.00 ± 1.27µM). All four compounds contain the flavonoid phenylbenzopyrone nucleus. Based on BZD-S binding, the order of affinity among these four compounds was wogonin > baicalein > scutellarein > baicalin.
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Dr. Hong Xue
Department of Biochemistry
Hong Kong University of Science and Technology
Clear Water Bay
Kowloon
Hong Kong
Email: hxue@ust.hk
Phone: +852-2358-8707
Fax: +852-2358-1552