Planta Med 2000; 66(1): 86-88
DOI: 10.1055/s-0029-1243119
Letter

© Georg Thieme Verlag Stuttgart · New York

Activity of Solidagenone and their Semisynthetic Derivatives on the Glucocorticoid-Mediated Signal Transduction

Iván B. Razmilic1 , Guillermo Schmeda-Hirschmann1 ,*
  • 1Instituto de Química de Recursos Naturales, Universidad de Talca, Talca, Chile
Further Information

Publication History

Received: March 27, 1999

Accepted: July 4, 1999

Publication Date:
24 November 2009 (online)

Abstract

The labdane diterpene solidagenone and four semisynthetic derivatives were assessed for effects on the glucocorticoid-mediated signal transduction. Solidagenone and the derivatives proved to be active with IC50 values between 1 and 25 µg/mL. All compounds were cytotoxic towards L 1210, BHK and COS 7 cells with IC50 from 10–100 µg/mL.

References

Dr. Guillermo Schmeda-Hirschmann

Instituto de Química de Recursos Naturales

Universidad de Talca

Casilla 747

Talca

Chile

Email: schmeda@pehuenche.utalca.cl

Fax: +56 71 200 448