Antinociceptive Activity of I3,II8-Binaringenin, a Biflavonoid Present in Plants of the Guttiferae

Abstract

This paper describes the antinociceptive action of I3,II8-binaringenin (GB-1a), a biflavonoid isolated from Clusia columnaris and present in several plants of the family Guttiferae, in a writhing test and a formalin test. It was found that it exhibits potent and dose-related antinociceptive action in both experimental models, with ID₅₀ values of 22µmol/kg against the writhing test and 28µmol/kg against the second phase of the formalin test. It was more potent than some well-known analgesic drugs used as reference. Based on a hot- plate test its mechanism of action seems to be unrelated with the opioid receptors.

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