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Planta Med 2000; 66(1): 80-81
DOI: 10.1055/s-0029-1243116
Letter

© Georg Thieme Verlag Stuttgart · New York

Furoquinolines with Antiplatelet Aggregation Activity from Leaves of Melicope confusa

Keh-Shaw Chen1 , Ya-Ling Chang2 , Che-Ming Teng2 , Chieh-Fu Chen3 , Yang-Chang Wu3 , 4 ,*
  • 1Ta-Jen Pharmaceutical Junior College, Ping Tung Hsien, Taiwan
  • 2Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
  • 3National Research Institute of Chinese Medicine, Taipei, Taiwan
  • 4Graduate Institute of Natural Products, Kaohsiung Medical College, Kaohsiung, Taiwan
Further Information

Publication History

Received: May 6, 1999

Accepted: June 12, 1999

Publication Date:
24 November 2009 (online)

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Abstract

Using antiplatelet aggregation as a guide for fractionation, four furoquinoline-type alkaloids, confusameline (1), skimmianine (2), kokusaginine (3), and O-methylconfusameline (4), were isolated from the leaves of Melicope confusa. All compounds showed significant antiplatelet aggregation activity.

References

  • 1 Li H I, Liu T S, Huang T C, Koyama T, DeVol C E. Flora of Taiwan. Taipei, Taiwan; Epoch Vol. III 1976: p. 515-517
    PubMedGoogle Scholar
  • 2 Yang T H, Lu S T, Wang S J, Wang T W, Lin J H, Chen I S. Yakugaku Zasshi 1971 91: 782-786
    PubMed
  • 3 Jong T T, Wu T S. Phytochemistry 1989 28: 245-246
    PubMed
  • 4 Jong T T, Wu T S. J Chem Research (S). 1989 8: 237-240
    PubMedGoogle Scholar
  • 5 Chan J A, Shultis E A, Carr S A, DeBrosse C W, Eggleston D S, Francis T A, Hyland L J, Johson W P, Killmer L b, Staiger D B, Westleg J W. J Org Chem 1989 54: 2098-2103
    PubMed
  • 6 Favel M T H, Gleye J, Moulis C, Blasco F, Stanislas E. Phytochemistry 1981 20: 2058-2059
    PubMed
  • 7 Higa M Y, Yogi S, Hokama K. Yakugaku Zasshi 1987 107: 954-958
    PubMed
  • 8 Ahond A, Picot F, Potier P, Poupat C, Sevenet T. Phytochemistry 1978 17: 166-167
    PubMed
  • 9 Hou R S, Duh C Y, Wang S K, Chang T T. Phytochemistry 1994 35: 271-272
    PubMed
  • 10 Chen I S, Lin Y C, Tsai I L, Teng C M, Ko F N, Ishikawa T, Ishii H. Phytochemistry 1995 39: 1091-1097
    PubMed
  • 11 Paulini H, Waibel R, Schimmer O. Mutat Res 1989 227: 179-186
    PubMed
  • 12 Chen K S, Ko F N, Teng C M, Wu Y C. Planta Med 1996 62: 133-136
    PubMed

Prof. Yang-Chang Wu

Graduate Institute of Natural Products

Kaohsiung Medical University

Kaohsiung 807

Taiwan

Email: yachwu@cc.kmc.edu.tw

Fax: +886-7-3114773

Phone: +886-7-3121101 ext. 2197

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