Aromatase and Sulfatase Inhibitors from Lepiota americana

Dong-Seon Kim; Hyeh-Jean Jeong; Krishna P. L. Bhat; So-Young Park; Soo-Hyon Kang; Eun-Hwa Yoo; Minna Lee; Hang-Woo Lee; Robert J. Krueger; Darrick S. H. L. Kim*

doi:10.1055/s-0029-1243115

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Planta Med 2000; 66(1): 78-79
DOI: 10.1055/s-0029-1243115

Letter

Aromatase and Sulfatase Inhibitors from Lepiota americana

Dong-Seon Kim¹ ^, ² , Hyeh-Jean Jeong¹ ^, ² , Krishna P. L. Bhat¹ , So-Young Park¹ , Soo-Hyon Kang¹ , Eun-Hwa Yoo¹ , Minna Lee¹ , Hang-Woo Lee¹ , Robert J. Krueger³ , Darrick S. H. L. Kim¹ ^,*

¹Program for Collaborative Research in the Pharmaceutical Sciences (M/C 877) and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.
²First two authors made an equal contribution
³School of Pharmacy, Ferris State University, Big Rapids, MI, U.S.A.

Further Information

Publication History

Received: February 19, 1999

Accepted: July 17, 1999

Publication Date:
24 November 2009 (online)

Also available at

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Abstract

From an edible mushroom Lepiota americana Pk., (Agaricaceae), 2-aminophenoxazin-3-one that inhibited aromatase at IC_50 =5.7µM and 3β-hydroxy-5,8-epidioxyergosta-6,22-diene that inhibited sulfatase at IC_50 =0.9µM were isolated. Neither 2-aminophenoxazin-3-one was active against sulfatase nor was 3β-hydroxy-5,8-epidioxyergosta- 6,22-diene active against aromatase.

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Prof. Dr. Darrick S. H. L. Kim

Program for Collaborative Research in the Pharmaceutical Sciences (M/C 877) and Department of Medicinal Chemistry and Pharmacognosy

College of Pharmacy

University of Illinois at Chicago

833 South Wood St.

Chicago, IL 60612

U.S.A.

Email: dshlkim@uic.edu

Fax: +1(312)-413-5894

Phone: +1(312)-996-1230