Planta Med 2000; 66(1): 78-79
DOI: 10.1055/s-0029-1243115
Letter

© Georg Thieme Verlag Stuttgart · New York

Aromatase and Sulfatase Inhibitors from Lepiota americana

Dong-Seon Kim1 , 2 , Hyeh-Jean Jeong1 , 2 , Krishna P. L. Bhat1 , So-Young Park1 , Soo-Hyon Kang1 , Eun-Hwa Yoo1 , Minna Lee1 , Hang-Woo Lee1 , Robert J. Krueger3 , Darrick S. H. L. Kim1 ,*
  • 1Program for Collaborative Research in the Pharmaceutical Sciences (M/C 877) and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.
  • 2First two authors made an equal contribution
  • 3School of Pharmacy, Ferris State University, Big Rapids, MI, U.S.A.
Further Information

Publication History

Received: February 19, 1999

Accepted: July 17, 1999

Publication Date:
24 November 2009 (online)

Abstract

From an edible mushroom Lepiota americana Pk., (Agaricaceae), 2-aminophenoxazin-3-one that inhibited aromatase at IC50 = 5.7µM and 3β-hydroxy-5,8-epidioxyergosta-6,22-diene that inhibited sulfatase at IC50 = 0.9µM were isolated. Neither 2-aminophenoxazin-3-one was active against sulfatase nor was 3β-hydroxy-5,8-epidioxyergosta- 6,22-diene active against aromatase.

References

Prof. Dr. Darrick S. H. L. Kim

Program for Collaborative Research in the Pharmaceutical Sciences (M/C 877) and Department of Medicinal Chemistry and Pharmacognosy

College of Pharmacy

University of Illinois at Chicago

833 South Wood St.

Chicago, IL 60612

U.S.A.

Email: dshlkim@uic.edu

Fax: +1(312)-413-5894

Phone: +1(312)-996-1230