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DOI: 10.1055/s-0029-1243115
© Georg Thieme Verlag Stuttgart · New York
Aromatase and Sulfatase Inhibitors from Lepiota americana
Publication History
Received: February 19, 1999
Accepted: July 17, 1999
Publication Date:
24 November 2009 (online)
Abstract
From an edible mushroom Lepiota americana Pk., (Agaricaceae), 2-aminophenoxazin-3-one that inhibited aromatase at IC50 = 5.7µM and 3β-hydroxy-5,8-epidioxyergosta-6,22-diene that inhibited sulfatase at IC50 = 0.9µM were isolated. Neither 2-aminophenoxazin-3-one was active against sulfatase nor was 3β-hydroxy-5,8-epidioxyergosta- 6,22-diene active against aromatase.
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Prof. Dr. Darrick S. H. L. Kim
Program for Collaborative Research in the Pharmaceutical Sciences (M/C 877) and Department of Medicinal Chemistry and Pharmacognosy
College of Pharmacy
University of Illinois at Chicago
833 South Wood St.
Chicago, IL 60612
U.S.A.
Email: dshlkim@uic.edu
Fax: +1(312)-413-5894
Phone: +1(312)-996-1230