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DOI: 10.1055/s-0029-1243113
© Georg Thieme Verlag Stuttgart · New York
Potentiating Effect of Obacunone from Dictamnus dasycarpus on Cytotoxicity of Microtuble Inhibitors, Vincristine, Vinblastine and Taxol
Publication History
Received: March 31, 1999
Accepted: August 21, 1999
Publication Date:
24 November 2009 (online)
Abstract
The limonoid triterpene, obacunone, was found to enhance the cytotoxicity of vincristine against L1210 cells by approximately 10-fold. Further, it was found that the cytotoxicity of other microtubule inhibitors such as vinblastine and taxol in drug-sensitive KB-3 – 1 cells as well as in multidrug-resistant KB- V1 cells was enhanced greatly in the presence of obacunone. On the other hand, there was no remarkable potentiating effect of obacunone on the cytotoxicity of other antineoplastic drugs such as adriamycin, cisplatin or 5-fluorouracil. From these results, it is implied that the potentiating action of obacunone may be limited to microtubule inhibitors.
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Ki Hwan Bae
College of Pharmacy
Chungnam National University
Taejon 305–764
Korea