Planta Med 2000; 66(1): 74-76
DOI: 10.1055/s-0029-1243113
Letter

© Georg Thieme Verlag Stuttgart · New York

Potentiating Effect of Obacunone from Dictamnus dasycarpus on Cytotoxicity of Microtuble Inhibitors, Vincristine, Vinblastine and Taxol

HyunJu Jung1 , Dai-Eun Sok1 , YoungHo Kim1 , ByungSun Min1 , JongPill Lee2 , KiHwan Bae1 ,*
  • 1College of Pharmacy, Chungnam National University, Taejon, Korea
  • 2Natural Medicinal Product Division, Korea Food & Drug Administration, Seoul, Korea
Further Information

Publication History

Received: March 31, 1999

Accepted: August 21, 1999

Publication Date:
24 November 2009 (online)

Abstract

The limonoid triterpene, obacunone, was found to enhance the cytotoxicity of vincristine against L1210 cells by approximately 10-fold. Further, it was found that the cytotoxicity of other microtubule inhibitors such as vinblastine and taxol in drug-sensitive KB-3 – 1 cells as well as in multidrug-resistant KB- V1 cells was enhanced greatly in the presence of obacunone. On the other hand, there was no remarkable potentiating effect of obacunone on the cytotoxicity of other antineoplastic drugs such as adriamycin, cisplatin or 5-fluorouracil. From these results, it is implied that the potentiating action of obacunone may be limited to microtubule inhibitors.

References

Ki Hwan Bae

College of Pharmacy

Chungnam National University

Taejon 305–764

Korea