Skull Base 2010; 20(1): 027-033
DOI: 10.1055/s-0029-1242982
ORIGINAL ARTICLE

© Thieme Medical Publishers

A Prospective Evaluation of Short-Term Health-Related Quality of Life in Patients Undergoing Anterior Skull Base Surgery

Abraham Abergel1 , Dan M. Fliss1 , Nevo Margalit2 , 3 , Ziv Gil1 , 3 , 4
  • 1Department of Otolaryngology–Head and Neck Surgery, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
  • 2Department of Neurosurgery, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
  • 3The Skull Base Surgery Service, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
  • 4The Laboratory for Applied Cancer Research, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
Further Information

Publication History

Publication Date:
22 January 2010 (online)

ABSTRACT

We evaluated the health-related quality of life (QOL) of patients undergoing anterior skull base tumor resection. The Anterior Skull Base Surgery QOL questionnaire, a disease-specific multidimensional instrument dedicated to this population, was used to collect and prospectively analyze demographic, medical, and QOL data on 48 patients. Thirty-nine patients completed the questionnaire preoperatively and at 6 and 12 months postoperatively. Seventeen patients (44%) had malignant histology and 22 (56%) had benign tumors. The overall QOL score decreased significantly at 6 months postoperatively (p < 0.05) and improved significantly at 12 months postoperatively (p < 0.04). The emotional domain improved significantly at 12 months postoperatively compared with the preoperative scores (p < 0.03). Patients with malignant tumors had lower scores at 6 months postoperatively compared with patients with benign lesions (p < 0.002), although the scores for both groups at 12 months postoperatively were similar. Adjuvant radiation therapy was associated with a poor QOL (p < 0.005). The results of this prospective study show that the overall deteriorated QOL of patients after anterior skull base tumor resection returns to baseline by 1 year after surgery. Histology and radiotherapy are significant predictors of health-related QOL in this population.

REFERENCES

Ziv Gil, M.D. , Ph.D. 

The Skull Base Surgery Service, Department of Otolaryngology–Head and Neck Surgery

Tel-Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel

Email: ziv@baseofskull.org