Glycyrrhiza glabra L.

Zusammenfassung

Die Süßholzwurzel besaß in allen großen europäischen und asiatischen Kulturen eine herausragende Rolle für verschiedene Indikationen. Auch heute ist sie ein fester Bestandteil der modernen Phytotherapie, besonders bei Katarrhen der Bronchien und bei Magenbeschwerden. Zahlreiche Forschungsaktivitäten weltweit geben Anlass zu der Hoffnung, dass die Süßholzwurzel in Zukunft auch für andere Anwendungsgebiete eingesetzt werden könnte, z.B. bei viralen Infektionen, und dass das Phänomen Süßholz seinen Triumphzug durch alle Epochen und Kulturen fortsetzt.

Summary

Glycyrrhiza glabra L. A fascinating medicinal herb with a long tradition

More than 5000 publications with the key words Glycyrrhetinic/Glycyrrhizinic acid, Glycyrrhizin and Liquorice/Licorice in the International Library of Medicine verify the great importance of liquorice roots in modern science. Liquorice root is a significant medicinal herb due to its large spectrum of pharmacological effects and the numerous traditional indications in Asian and European cultures, e.g. bronchial catarrh, gastric and duodenal ulcers. Recent scientific knowledge about the liquorice root gives hope that a new important chapter in the fascinating history of this phenomenal medicinal herb may be written because of its antiviral effects.

Schlüsselwörter

Glycyrrhiza glabra L. - Fabaceae - Glycyrrhizin - Influenza - antioxidativ - antiviral - antihepatotoxisch - Pseudohyperaldosteronismus

Key words

Glycyrrhiza glabra L. - Fabaceae - liquorice - licorice - glycyrrhizin - influenza - antioxidative - antiviral - antihepatotoxic - antiatherogenic - pseudohyperaldosteronism

Literatur

• 1 Chopra RN, Chopra IC, Handa KL, Kapur LD. Indigenous Drugs of India. Calcutta; Dhur & Sons Private Ltd. 1958 183
• 2 Lucas R. Nature’s Medicines: The Folklore, Romance & Value of Hebal Remedies. London; Spearman 1963: 89-94
• 3 Houseman PA. Licorice: Putting a Weed to Work. London: The Royal Institute of Chemistry of Great Britain and Ireland.  1994;  3 10-15
• 4 Plinius CP. Plini Secundi Naturalis historiae libri XXXVII, XI, 119; XXII, 11; XXV, 43. II: Teubneri, Lipsiae, 1875; IV: Teubneri, Lipsiae, 1897
• 5 Yaginuma T, Izumi R, Yasui H, et al.. Effect of traditional herbal medicine on serum testosterone levels and its induction of regular ovulation in hyperandrogenic and oligomenorrheic women.  Nippon Sanka Fujinka Gakkai Zasshi. 1982;  34 939-944
• 6 Avicenna. Liber canonis de medicinis cordialibus cantica de removendis nocumentis in regimine sanitatis. De syrupo acetoso, II, 2, 437. Venetiis; Apud Iuntas 1562
• 7 Li W, Asada Y, Yoshikawa T. Antimicrobial flavonoids from Glycyrrhiza glabra hairy root cultures.  Planta Med. 1998;  64 746-747
• 8 Fukai T, Cai BS, Maruno K, et al.. An isoprenylated flavanone from Glycyrrhiza glabra and rec-assay of licorice phenols.  Phytochemistry. 1998;  49 2005-2013
• 9 Nomura T, Fukai T. Phenolic constituents of licorice (Glycyrrhiza species).  Fortschr Chem Org Naturst. 1998;  73 1-158
• 10 Pompei R, Flore O, Marccialis MA, et al.. Glycyrrhizic acid inhibits virus growth and inactivates virus particles.  Nature. 1979;  281 689-690
• 11 Crance JM, Leveque F, Biziagos E, et al.. Studies on the mechanism of action of glycyrrhizin against hepatitis A virus replication in vitro.  Antiviral Res. 1994;  23 63-76
• 12 Cinatl J, Morgenstern B, Bauer G, et al.. Glycyrrhizin, an active component of liquorice roots, and replication of SARSassociated coronavirus.  Lancet. 2003;  361 2045-2046
• 13 Rossum van TG, Vulto AG, Man de RA, et al.. Glycyrrhizin as a potential treatment for chronic hepatitis C.  Aliment Pharmacol Ther. 1998;  12 199-205
• 14 Tsubota A, Kumada H, Arase Y, et al.. Combined ursodeoxycholic acid and glycyrrhizin therapy for chronic hepatitis C virus infection: a randomized controlled trial in 170 patients.  Eur J Gastroenterol Hepatol. 1999;  11 1077-1083
• 15 Ikeda T, Yokomizo K, Okawa M, et al.. Antiherpes virus type 1 activity of oleanane-type triterpenoids.  Biol Pharm Bull. 2005;  28 1779-1781
• 16 Wolkerstorfer A, Kurz H, Bachhofner N, Szolar O. Glycyrrhizin inhibits influenza A virus uptake into the cell.  Antiviral Res. 2009;  83 171-178
• 17 Utsunomiya T, Kobayashi M, Pollard RB, Suzuki F. Glycyrrhizin, an active component in licorice roots, reduces morbidity and mortality of mice infected with letal doses of influenza virus.  Antimicrob Agents Chemother. 1997;  41 551-556
• 18 Revers FZ. Ned. T.  Geneesk. 1946;  90 135-137
• 19 Krausse R, Bielenberg J, Blaschek W, Ullmann U. In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites.  J Antimicrob Chemother. 2004;  54 243-246
• 20 Fukai T, Marumo A, Kaitou K, et al.. Anti-Helicobacter pylori flavonoids from licorice extract.  Life Science. 2002;  71 1449-1463
• 21 Olukoga A, Donaldson D. Liquorice and its health implications.  J R Soc Promot Health. 2000;  120 83-89
• 22 Kiso Y, Tohkin M, Hikino H, et al.. Mechanism of antihepatotoxic activity of glycyrrhizin. I: Effect on free radical generation and lipid peroxidation.  Planta Med. 1984;  50 298-302
• 23 Abe N, Ebina T, Ishida N. Interferon induction by glycyrrhizin and glycyrrhetinic acid in mice.  Microbiol Immunol. 1982;  26 535-539
• 24 Hatano T, Shintani Y, Aga Y, et al.. Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillinresistant Staphylococcus aureus.  Chem Pharm Bull. 2000;  48 1286-1292
• 25 Shibata S. A drug over the millennia. Pharmacognosy, chemistry, and pharmacology of licorice.  Yakugaku Zasshi. 2000;  120 849-862
• 26 Wang JY, Guo JS, Li H, Liu SL, Zern MA. Inhibitory effect of glycyrrhizin on NF-kappaB binding activity in CCl4-plus ethanol-induced liver cirrhosis in rats.  Liver. 1998;  18 180-185
• 27 Fujisawa Y, Sakamoto M, Matsushita M, et al.. Glycyrrhizin inhibits the lytic pathway of complement – possible mechanism of its antiinflammatory effect on liver cells in viral hepatitis.  Microbiol Immunol. 2000;  44 799-804
• 28 Haraguchi H, Ishikawa H, Mizutani K, et al.. Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata .  Bioorg Med Chem. 1998;  6 339-347
• 29 Fuhrman B, Buch S, Vaya J, et al.. Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice.  Am J Clin Nutr. 1997;  66 267-275
• 30 Haraguchi H, Yoshida N, Ishikawa H, et al.. Protection of mitochondrial functions against oxidative stresses by isoflavans from Glycyrrhiza glabra .  J Pharm Pharmacol. 2000;  52 219-223
• 31 Carmeli E, Harpaz Y, Kogan NN, Fogelman Y. The effect of an endogenous antioxidant glabridin on oxidized LDL.  J Basic Clin Physiol Pharmacol. 2008;  19 49-63
• 32 Lee YM, Hirota S, Jippo-Kanemoto T, et al.. Inhibition of histamine synthesis by glycyrrhetinic acid in mast cells cocultured with Swiss 3T3 fibroblasts.  Int Arch Allergy Immunol. 1996;  110 272-277
• 33 Veraldi S, De Micheli P, Schianchi R, Lunardon I. Treatment of pruritus in mild to moderate atopic dermatitis with a topical non-steroidal agent.  J Drugs Dermatol. 2009;  8 537-539
• 34 Adhikari A, Devkota HP, Takano A, et al.. Screening of Nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition.  Int J Cosmet Sci. 2008;  30 353-360
• 35 Nerya O, Vaya J, Musa R, et al.. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice root.  J Agric Food Chem. 2003;  51 1201-1207
• 36 Armanini D, Nacamulli D, Francini-Pesenti F, et al.. Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application.  Steroids. 2005;  70 538-542
• 37 Suzuki H, Ohta T, Takino T, et al.. Effects of glycyrrhizin on biochemical tests in patients with chronic hepatitis. Double blind trial.  Asian Med J. 1983;  26 423-438
• 38 Zhang U, Liu F, Sun B, Li G. Acta Pharmacol Sin.  1986;  7 175-177
• 39 Epstein MT, Espiner EA, Donald RA, Hughes H. Effect of eating liquorice on the reninangiotensin aldosterone axis in normal subjects.  Brit Med J. 1977;  1(6059) 488-490
• 40 Ulmann A, Menard J, Corvol P. Binding of glycyrrhetinic acid to kidney mineralocorticoid and glucocorticoid receptors.  Endocrinology. 1975;  97 46-51
• 41 Armanini D, Karbowiak I, Funder JW. Affinity of liquorice derivates for mineralocorticoid and glucocorticoid receptors.  Clin Endocrinol (Oxford). 1983;  19 609-612
• 42 Tamaya T, Sato S, Okada HH. Possible mechanism of steroid action of the plant herb extracts glycyrrhizin, glycyrrhetinic acid, and paeoniflorin: inhibition by plant herb extracts of steroid protein binding in the rabbit.  Am J Obstet Gynecol. 1986;  155 1134-1139
• 43 Steward OM, Edwards CR. Specificity of the mineralocorticoid receptor. Crucial role of 11beta-hydroxysteroid dehydrogenase.  Trends Endocrinol Metab. 1990;  1 225-230
• 44 Tamura Y, Nishikawa T, Yamada K, et al.. Effects of glycyrrhetinic acid and its derivates on delta 4-5 alpha- and 5 beta-reductase in rat liver.  Arzneimittelforschung/Drug Research. 1979;  29 647-649
• 45 Seckl JR. 11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?.  Front Neuroendocrinol. 1997;  18 49-99
• 46 Kato H, Kanaoka M, Yano S, Kobayashi M. 3-Monoglucuronyl-glycyrrhetinic acid is a major metabolite that causes licorice induced pseudoaldosteronism.  J Clin Endocrinol Metab. 1995;  80 1929-1933
• 47 Classen-Houben D, Schuster D, Cunha Da T, et al.. Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alphaglycyrrhetinic and not 18beta-glycyrrhetinic acid.  J Steroid Biochem Molecular Biol. 2009;  113 248-252
• 48 McCalla CO, Nacharaju VL, Muneyyirci-Delale O, et al.. Placental 11beta-hydroxysteroid dehydrogenase activity in normotensive and pre-eclamptic pregnancies.  Steroids. 1998;  63 511-515
• 49 Oh HM, Lee S, Park YN, et al.. Ammonium glycyrrhizinate protects gastric epithelial cells from hydrogen peroxide-induced cell death.  Exp Biol Med (Maywood). 2009;  234 263-277
• 50 Shin YW, Bae EA, Lee B, et al.. In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components.  Planta Med. 2007;  73 257-261
• 51 Park HY, Park SH, Yoon HK, et al.. Anti-allergic activity of 18beta-glycyrrhetinic acid-3-Obeta-D-glucuronide.  Arch Pharm Res. 2004;  27 57-60
• 52 Vloten Van P, Savelkoul TJF, Groot De G, et al.. Onderzoek naar de biologische effecten van verschillende doseringen glycyrrhizine bij menselijke vrijwilligers (pilot study). Bilthoven; Rijksinstituut voor Volksgezondheid en Milieu RIVM rapport nr. 348801 001 1989
• 53 Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin.  Regul Toxicol Pharmacol. 2006;  46 167-192
• 54 European Commission, Scientific Committee on Food. Opinion of the Scientific Committee on Food on glycyrrhizinic acid and its ammonium salt. SCF/CS/ADD/EDUL/225 Final. Brussels; 10 April 2003 http://ec.europa.eu/food/fs/sc/scf/out186_en.pdf
• 55 Deutsche Forschungsgemeinschaft. Niederschrift über die Sitzung der ad hoc-Arbeitsgruppe der Senatskommission zur Beurteilung der gesundheitlichen Unbedenklichkeit von Lebensmitteln. Bonn; 20. April 1990