Neuropediatrics 2009; 40(4): 199-200
DOI: 10.1055/s-0029-1241187
Short Communication

© Georg Thieme Verlag KG Stuttgart · New York

Efficacy of Continuous Acyclovir Infusion in Neonatal Herpes Virus Encephalitis

Y. Kakisaka1 , M. Ishitobi1 , K. Wakusawa1 , K. Haginoya1 , N. Togashi1 , T. Kitamura1 , N. Hino-Fukuyo1 , I. Sato1 , M. Uematsu1 , S. Tsuchiya1
  • 1Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan
Further Information

Publication History

received 28.07.2009

accepted 09.09.2009

Publication Date:
04 February 2010 (online)


We have successfully eliminated herpes simplex virus-2 from the central nervous system in a case of neonatal herpes simplex virus encephalitis with a continuous acyclovir infusion. A male infant delivered from a healthy 22-year-old woman without genital or systemic herpes symptoms around delivery began to develop fever and intractable seizures. He was started on intermittent intravenous acyclovir (20 mg/kg every 8 h) based on the diagnosis of herpes encephalitis. The virus was not eliminated with intermittent acyclovir and vidarabine, while continuous acyclovir was ultimately effective in eliminating herpes simplex virus from his central nervous system. This report demonstrates the efficacy of continuous acyclovir infusion in neonatal herpes simplex virus encephalitis.



Yosuke Kakisaka, MD 

Department of Pediatrics

Tohoku University School of Medicine

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980-8574 Miyagi


Phone: +81/22/717 72 87

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