Arisanschinins A–E, Lignans from Schisandra arisanensis Hay.

Chin-Cheng Liu; Mohamed H. Abd El-Razek; Chia-Ching Liaw; Yuan-Bin Cheng; Chien-Kuang Chen; Ching-Te Chien; Yao-Haur Kuo; Shorong-Shii Liou; Ya-Ching Shen

doi:10.1055/s-0029-1241014

Planta Medica, Table of Contents

Planta Med 2010; 76(14): 1605-1610
DOI: 10.1055/s-0029-1241014

Natural Product Chemistry

Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Arisanschinins A–E, Lignans from Schisandra arisanensis Hay.

Chin-Cheng Liu¹ , Mohamed H. Abd El-Razek¹ , Chia-Ching Liaw¹ , Yuan-Bin Cheng¹ , Chien-Kuang Chen¹ , Ching-Te Chien² , Yao-Haur Kuo³ , Shorong-Shii Liou⁴ , Ya-Ching Shen¹

¹School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
²Division of Silviculture, Taiwan Forestry Research Institute, Taipei, Taiwan
³National Research Institute of Chinese Medicine, Taipei, Taiwan
⁴Department of Pharmacy, Tajen University, Ping Tung, Taiwan

Abstract

Four new oxygenated dibenzocyclooctadiene lignans, arisanschinins A–D (1–4), and a new 1,4-bis(phenyl)-2,3-dimethylbutane lignan, arisanschinin E (5), together with 15 known compounds, were isolated from the EtOAc-soluble fraction of the aerial parts of Schisandra arisanensis Hay. The structures of 1–5 were elucidated on the basis of extensive spectroscopic analyses, including 2D NMR (HMQC, HMBC, and NOESY) experiments. The configurations of the biphenyl and octadiene moieties were deduced from circular dichroism (CD) and NOESY spectra, respectively. Compound 1 showed significant inhibition of α-glucosidase in vitro. The radical-scavenging activities of these compounds were evaluated using DPPH.

Key words

Schisandraceae - Schisandra arisanensis - lignans - dibenzocyclooctadiene - α‐glucosidase inhibition

Full Text

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Prof. Ya-Ching Shen

School of Pharmacy
College of Medicine
National Taiwan University

12F, No. 1, Sec.1, Jen-Ai Rd.

100 Taipei

Taiwan, Province of China

Phone: + 88 62 23 12 34 56 ext. 6 22 26

Fax: + 88 6 02 23 91 90 98

Email: ycshen@ntu.edu.tw

Supplementary Material

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