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Planta Med 2010; 76(14): 1525-1529
DOI: 10.1055/s-0029-1241003
Pharmacology
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Fo Shou San, an Ancient Herbal Decoction Prepared from Rhizoma Chuanxiong and Radix Angelicae Sinensis, Stimulates the Production of Hemoglobin and Erythropoietin in Cultured Cells

Cathy Wen Chuan Bi1 , Heidi Qun Hui Xie1 , Li Xu1 , Jun Li1 , Anna Wing Han Cheung1 , Judy Ting Ting Zhu1 , Yu Zhong Zheng1 , Vicky Ping Chen1 , David Tai Wai Lau1 , Roy Chi Yan Choi1 , Tie Jie Wang1 , 2 , Tina Ting Xia Dong1 , Karl Wah Keung Tsim1
  • 1Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, PR China
  • 2Shenzhen Municipal Institute for Drug Control, Shenzhen, PR China
Weitere Informationen

Publikationsverlauf

received Sept. 24, 2009 revised February 8, 2010

accepted February 17, 2010

Publikationsdatum:
22. März 2010 (online)

    Lizenzen und Reprints

Abstract

Fo Shou San (FSS) is an ancient herbal decoction comprised of Rhizoma Chuanxiong (RC; Chuanxiong) and Radix Angelicae Sinensis (RAS; Danggui) in a ratio of 2 : 3. It is mainly prescribed for patients having a blood deficiency. This combination is considered the most popular herb pair among Chinese medicines; however, the rationale of having these two chemically similar herbs within the decoction has historically not been made clear. Here, we attempted to reveal the chemical and biological properties of this decoction as a means to deduce its mechanism of action. The effects of FSS were determined in different cell culture models. With respect to stimulation of blood circulation, FSS inhibited ADP-mediated platelet aggregation in a dose-dependent manner. In order to reveal the hematopoietic effect of this decoction, FSS was applied onto cultured K562 human leukemia cells and Hep3B human hepatocellular carcinoma cells. Application of FSS in cultured K562 cells inhibited cell proliferation and subsequently induced the production of hemoglobin. Additionally, the mRNA expression of erythropoietin (EPO) was induced in a dose-dependent manner when FSS was applied to Hep3B cells. The current results reveal the effects of FSS in different cell models, paving a direction for mechanistic studies.

Key words

Angelica sinensis - Ligusticum chuanxiong - Umbelliferae

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Prof. Karl W. K. Tsim

Department of Biology and Center for Chinese Medicine
The Hong Kong University of Science and Technology

Clear Water Bay Road

Hong Kong

PR China

Telefon: + 85 2 23 58 73 32

Fax: + 85 2 23 58 15 59

eMail: botsim@ust.hk

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