Planta Med 2010; 76(9): 897-902
DOI: 10.1055/s-0029-1240800
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Blumeaenes A–J, Sesquiterpenoid Esters from Blumea balsamifera with NO Inhibitory Activity

Ming Chen1 , 3 , Jiang-Jiang Qin1 , Jian-Jun Fu1 , Xiao-Jia Hu1 , Xiao-Hua Liu2 , Wei-Dong Zhang1 , 2 , Hui-Zi Jin1
  • 1School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P. R. China
  • 2Department of Phytochemistry, Second Military Medical University, Shanghai, P. R. China
  • 3Shanghai Institute for Food and Drug Control, Shanghai, P. R. China
Further Information

Publication History

received Sept. 29, 2009 revised Dec. 14, 2009

accepted Dec. 18, 2009

Publication Date:
25 January 2010 (online)

Abstract

Chemical examination of the ethanol extract of the aerial parts of Blumea balsamifera led to the isolation of ten new sesquiterpenoid esters, blumeaenes A–J (110), with 13 known flavonoids. Their structures were determined mainly by use of 1D and 2D NMR spectroscopic techniques. All sesquiterpenoid esters were tested for their inhibitory activity against LPS-induced NO production in RAW264.7 macrophages. Compounds 1, 4 and 5 showed slight inhibitory effect on the production of NO with IC50 values of 40.06, 46.35 and 57.80 µg/mL, respectively.

References

Dr. Hui Zi
Jin
Dr. Wei Dong
Zhang

School of Pharmacy
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